Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9210.011 | uM | 212.54010 | 365.14720 | -0.9298 | -1.0000 | 2.0301 | 0.2289 | 0.9851 | 0.9440 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9157.001 | uM | 5.53880 | 13.18950 | -0.6286 | -1.0000 | 1.2662 | 0.2774 | 0.8652 | 0.9211 | |
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| BT-549 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12305.167 | uM | 1.61670 | 6.36660 | -0.7128 | -1.0000 | 0.8015 | 0.3323 | 0.9667 | 2.8814 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5894.067 | uM | 1.62180 | 3.48940 | -0.9288 | -1.0000 | 1.4339 | 0.3983 | 0.9581 | 1.5647 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 12291.165 | uM | 0.41097 | 147.3160 | -0.1202 | -1.0000 | 0.1868 | 0.4109 | 0.6135 | 0.5602 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7435.084 | uM | 0.27572 | 0.41327 | -0.9997 | -1.0000 | 2.7144 | 0.7084 | 0.9961 | 0.8646 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12178.158 | uM | 1.57950 | 4.28540 | -0.8896 | -1.0000 | 1.1007 | 0.4947 | 0.9798 | 0.7379 | |
| BT-20 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10581.14 | uM | 2.50810 | 5.45180 | -0.9836 | -1.0000 | 1.4150 | 0.6051 | 0.9839 | 0.9569 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14230.189 | uM | 0.27401 | 0.47494 | -1.0000 | -1.0000 | 1.9974 | 0.7978 | 0.9974 | 0.4635 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5895.067 | uM | 2.25070 | 4.57410 | -0.9091 | -1.0000 | 1.5491 | 0.3497 | 0.9692 | 1.4053 | |
| BT-549 | TNBC | Basal B | Nelfinavir | 12690.174 | uM | 9.7440 | 13.750 | -0.8879 | -1.0000 | 3.1900 | 0.1406 | 0.9994 | 2.4378 | |||
| BT-474 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7798.018 | uM | 0.07033 | 1.33570 | -0.8933 | -1.0000 | 0.3732 | 0.6131 | 0.8869 | 1.4461 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10880.149 | uM | 41.97630 | 133.38290 | 0.5726 | -1.0000 | 0.9503 | 0.0531 | 0.9147 | 1.6289 | |
| 21MT-1 | HER2amp | - | Nelfinavir | 13719.174 | uM | 10.30820 | 13.49270 | -0.9513 | -1.0000 | 4.0808 | 0.1693 | 0.9959 | 0.8124 | |||
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 11854.158 | uM | 24.60350 | 145.14930 | 0.2089 | -1.0000 | 0.6190 | 0.1259 | 0.9644 | 1.3776 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 11854.161 | uM | 34.51650 | 42.99810 | -0.3604 | -1.0000 | 5.0000 | 0.0676 | 0.9896 | 1.2085 | |
| AU565 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10880.154 | uM | 1.08830 | 3.54840 | -0.8526 | -1.0000 | 0.9295 | 0.4164 | 0.9828 | 1.7853 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5895.095 | uM | 0.14338 | 0.76637 | -0.9501 | -1.0000 | 0.6554 | 0.6829 | 0.9483 | 1.4629 | |
| BT-474 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.085 | uM | 25.84930 | 58.21470 | -0.9937 | -1.0000 | 1.3532 | 0.3254 | 0.9707 | 0.8847 | |
| BT-483 | HR+ | Luminal | L-779450 | BRAF | MAPK | 11855.161 | uM | 6.06830 | 274.20550 | 0.0925 | -1.0000 | 0.2883 | 0.2708 | 0.7203 | 0.5957 | |
| AU565 | HER2amp | Luminal | Methylglyoxal | 13149.184 | uM | 130.14740 | 469.55390 | -0.9992 | -1.0000 | 0.8562 | 0.7768 | 0.9575 | 0.8650 | |||
| AU565 | HER2amp | Luminal | Methylglyoxal | 13030.184 | uM | 50.30640 | 183.32630 | -1.0000 | -1.0000 | 0.8496 | 0.9024 | 0.9717 | 0.5725 | |||
| HCC1428 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 10441.093 | uM | 4.87910 | 7.92130 | -0.9402 | -1.0000 | 2.2671 | 0.2803 | 0.9867 | 1.1458 | |
| HCC1428 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 7442.1 | uM | 8.010 | 14.52550 | -0.9818 | -1.0000 | 1.8457 | 0.3253 | 0.9730 | 0.8780 |