Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5903.09 | uM | 14.23390 | 26.11670 | -0.9964 | -1.0000 | 1.8101 | 0.5188 | 0.9862 | 0.9291 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 13091.177 | uM | 0.13548 | 0.2280 | -1.0000 | -1.0000 | 2.1106 | 0.8509 | 0.9450 | 0.7004 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 11854.158 | uM | 24.60350 | 145.14930 | 0.2089 | -1.0000 | 0.6190 | 0.1259 | 0.9644 | 1.3776 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9146.037 | uM | 0.15634 | 3.69020 | -0.9186 | -1.0000 | 0.3475 | 0.5819 | 0.8060 | 1.2617 | |
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5904.092 | uM | 7.68060 | 18.45430 | -0.9954 | -1.0000 | 1.2533 | 0.6283 | 0.9466 | 0.8933 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9163.011 | uM | 92.88920 | 177.40340 | -0.9636 | -1.0000 | 1.6980 | 0.2967 | 0.9963 | 0.6266 | |
| 600MPE | HR+ | Luminal | Mebendazole | 13091.174 | uM | 14.64610 | 480.70650 | 0.3243 | -1.0000 | 0.3147 | 0.2245 | 0.8786 | 0.7967 | |||
| BT-20 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 11854.161 | uM | 100.53860 | 466.86010 | 0.4990 | -1.0000 | 0.7155 | 0.1017 | 0.7789 | 1.2085 | |
| 600MPE | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 5899.066 | uM | 42.47440 | 128.71880 | 0.2966 | -1.0000 | 0.9909 | 0.1530 | 0.6806 | 0.7056 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| 600MPE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12224.165 | uM | 2.4860 | 3.88950 | -0.9804 | -1.0000 | 2.4546 | 0.6104 | 0.9030 | 0.9714 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5894.074 | uM | 9.28560 | 35.69030 | -0.7680 | -1.0000 | 0.8160 | 0.4044 | 0.9826 | 1.4541 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 5898.085 | uM | 0.26595 | 0.36220 | -0.9980 | -1.0000 | 3.5567 | 0.7703 | 0.9784 | 0.7048 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 12979.177 | uM | 0.02740 | 0.03413 | -1.0000 | -1.0000 | 5.0000 | 1.0789 | 0.9988 | 0.5647 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 7791.016 | uM | 34.63250 | 70.58790 | -0.6402 | -1.0000 | 1.5428 | 0.2456 | 0.8929 | 0.8138 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12224.165 | uM | 8.75170 | 136.14630 | 0.2719 | -1.0000 | 0.4003 | 0.2034 | 0.8983 | 0.9714 | |
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9163.026 | uM | 1.16670 | 17.90580 | -1.0000 | -1.0000 | 0.4023 | 0.8897 | 0.9004 | 0.3738 | ||
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10880.156 | uM | 0.57383 | 7.51240 | -0.8788 | -1.0000 | 0.4272 | 0.4508 | 0.8269 | 1.5288 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5898.074 | uM | 1.85990 | 6.61990 | -0.8905 | -1.0000 | 0.8654 | 0.5349 | 0.9882 | 0.7134 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5898.074 | uM | 1.85990 | 6.61990 | -0.8905 | -1.0000 | 0.8654 | 0.5349 | 0.9882 | 0.7134 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 5895.074 | uM | 10.48650 | 42.19930 | -0.7395 | -1.0000 | 0.7891 | 0.3710 | 0.9859 | 1.1218 | |
| 184B5 | NM | Basal | Chloroquine | 12979.177 | uM | 19.64650 | 24.47430 | -1.0000 | -1.0000 | 5.0000 | 0.1512 | 0.9526 | 0.5647 | |||
| 600MPE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5898.095 | uM | 0.05465 | 2.31930 | -0.9967 | -1.0000 | 0.2931 | 0.5721 | 0.6309 | 0.6975 | |
| HCC1143 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 9233.121 | uM | 17.63230 | 78.47640 | -0.0443 | -1.0000 | 0.7358 | 0.1290 | 0.9627 | 0.9468 | |
| HCC1143 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7810.006 | uM | 69.91230 | 288.45370 | -0.9802 | -1.0000 | 0.7752 | 0.5465 | 0.8937 | 0.9730 |