Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5894.067 | uM | 1.62180 | 3.48940 | -0.9288 | -1.0000 | 1.4339 | 0.3983 | 0.9581 | 1.5647 | |
| 600MPE | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5898.067 | uM | 5.29710 | 7.53220 | -0.9986 | -1.0000 | 3.1208 | 0.5757 | 0.9370 | 0.6532 | |
| 600MPE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12224.165 | uM | 6.5660 | 13.29760 | -0.9371 | -1.0000 | 1.5568 | 0.3611 | 0.9610 | 0.9714 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5895.067 | uM | 2.25070 | 4.57410 | -0.9091 | -1.0000 | 1.5491 | 0.3497 | 0.9692 | 1.4053 | |
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9157.034 | uM | 162.90980 | 696.84330 | -0.9646 | -1.0000 | 0.7559 | 0.4501 | 0.8634 | 1.0593 | ||
| 21MT-1 | HER2amp | - | Nelfinavir | 13719.174 | uM | 10.30820 | 13.49270 | -0.9513 | -1.0000 | 4.0808 | 0.1693 | 0.9959 | 0.8124 | |||
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7793.001 | uM | 5.6020 | 10.09590 | -0.8129 | -1.0000 | 1.8652 | 0.2425 | 0.9715 | 1.1508 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5895.095 | uM | 0.14338 | 0.76637 | -0.9501 | -1.0000 | 0.6554 | 0.6829 | 0.9483 | 1.4629 | |
| 600MPE | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12224.147 | uM | 2.79220 | 7.38130 | -0.9880 | -1.0000 | 1.1301 | 0.3828 | 0.9872 | 0.8621 | |
| 600MPE | HR+ | Luminal | Triciribine | AKT | AKT | 5899.074 | uM | 0.63713 | 68.74810 | 0.0341 | -1.0000 | 0.2347 | 0.3748 | 0.9523 | 0.8860 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9146.001 | uM | 2.55360 | 9.30180 | -0.6291 | -1.0000 | 0.8499 | 0.3663 | 0.8348 | 1.2878 | |
| AU565 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 10880.147 | uM | 20.07910 | 29.68650 | -0.8151 | -1.0000 | 2.8097 | 0.1900 | 0.9822 | 1.5262 | |
| BT-474 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.085 | uM | 25.84930 | 58.21470 | -0.9937 | -1.0000 | 1.3532 | 0.3254 | 0.9707 | 0.8847 | |
| AU565 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9146.12 | uM | 2.20640 | 6.19270 | -0.9837 | -1.0000 | 1.0645 | 0.7511 | 0.9901 | 1.1135 | |
| BT-20 | TNBC | Basal A | IKK16 | IKK | NFKB | 10385.093 | uM | 3.54330 | 4.41410 | -0.9989 | -1.0000 | 4.9997 | 0.3819 | 0.9982 | 0.6082 | |
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9158.123 | uM | 3.16810 | 8.29940 | -0.9937 | -1.0000 | 1.1408 | 0.4810 | 0.9711 | 0.8769 | ||
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9158.001 | uM | 5.49390 | 8.17950 | -0.9752 | -1.0000 | 2.7604 | 0.2511 | 0.9873 | 0.6988 | |
| 184B5 | NM | Basal | Afatinib | EGFR/HER2 | ErbB | 12566.165 | uM | 0.11327 | 1.15330 | -0.8618 | -1.0000 | 0.4734 | 0.6795 | 0.9291 | 1.7248 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5898.091 | uM | 0.32342 | 1.23240 | -0.9978 | -1.0000 | 0.8212 | 0.7254 | 0.9476 | 0.6159 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 12509.166 | uM | 8.56520 | 14.40640 | -0.7107 | -1.0000 | 2.1129 | 0.1672 | 0.9687 | 1.2847 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5899.067 | uM | 27.81920 | 110.71190 | -0.1721 | -1.0000 | 0.7954 | 0.2510 | 0.9003 | 0.9897 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 10385.065 | uM | 0.36381 | 5.4850 | -0.9923 | -1.0000 | 0.4049 | 1.1403 | 0.6735 | 0.6599 | |
| CAMA-1 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12647.174 | uM | 13.59380 | 18.90890 | -0.9897 | -1.0000 | 3.3289 | 0.3645 | 0.7716 | 0.9362 | |
| CAMA-1 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10755.146 | uM | 32.43130 | 85.79460 | 0.4848 | -1.0000 | 1.1293 | 0.1134 | 0.6407 | 0.8035 |