Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7553.066 | uM | inf | inf | 0.8384 | 0.8384 | 0.0000 | 0.1034 | 0.2803 | 0.9707 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12291.155 | uM | inf | inf | 0.8638 | 0.8638 | 0.0000 | 0.1956 | 0.2806 | 0.4532 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12178.135 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | -0.0119 | 0.2808 | 0.5524 | |
| MDA-MB-361 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10999.152 | uM | inf | inf | 0.7974 | 0.7974 | 0.0000 | 0.0618 | 0.2809 | 0.8426 | |
| SUM185PE | TNBC | Luminal | PD 98059 | MEK | MAPK | 12269.152 | uM | inf | inf | 0.1019 | 0.1019 | 0.0000 | 0.1402 | 0.2810 | 0.8791 | |
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7505.016 | uM | inf | inf | 0.8207 | 0.8207 | 0.0000 | 0.1123 | 0.2810 | 1.0721 | ||
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10938.151 | uM | inf | inf | 0.3561 | 0.3561 | 0.0000 | 0.2452 | 0.2832 | 1.0747 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9933.012 | uM | inf | inf | 0.1298 | 0.1298 | 0.0000 | 0.3783 | 0.2836 | 0.4114 | |
| HCC1419 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7440.095 | uM | inf | inf | 0.6165 | 0.6165 | 0.0000 | 0.2930 | 0.2845 | 0.5907 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| SUM225CWN | HER2amp | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10579.14 | uM | inf | inf | 0.6784 | 0.6784 | 0.0000 | 0.0743 | 0.2850 | 0.9303 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7816.017 | uM | inf | inf | 0.9626 | 0.9626 | 0.0000 | 0.1531 | 0.2853 | 1.2318 | |
| MDA-MB-134-VI | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7494.09 | uM | inf | inf | 0.5852 | 0.5852 | 0.0000 | 0.1382 | 0.2867 | 1.0823 | |
| MDA-MB-436 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7902.016 | uM | inf | inf | 0.6917 | 0.6917 | 0.0000 | 0.0572 | 0.2876 | 1.9004 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7475.069 | uM | inf | inf | 0.9609 | 0.9609 | 0.0000 | 0.0540 | 0.2883 | 2.7183 | |
| HCC1395 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7435.067 | uM | inf | inf | 0.6392 | 0.6392 | 0.0000 | 0.0374 | 0.2883 | 0.7691 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7464.095 | uM | inf | inf | 0.9059 | 0.9059 | 0.0000 | -0.0281 | -0.2886 | 0.5464 | |
| UACC-812 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10754.146 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0246 | -0.2891 | 1.2483 | |
| UACC-812 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10754.146 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0246 | -0.2891 | 1.2483 | |
| SUM102PT | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9777.124 | uM | inf | inf | 0.8331 | 0.8331 | 0.0000 | 0.0175 | 0.2896 | 0.6278 | |
| SUM225CWN | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 12098.161 | uM | inf | inf | 0.4834 | 0.4834 | 0.0000 | 0.1703 | 0.2896 | 1.4196 | |
| SUM159PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7918.016 | uM | inf | inf | 0.6825 | 0.6825 | 0.0000 | 0.1161 | 0.2905 | 3.1190 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7464.098 | uM | inf | inf | 0.9208 | 0.9208 | 0.0000 | 0.0740 | 0.2911 | 0.6305 | |
| SUM185PE | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 12269.16 | uM | inf | inf | 0.1892 | 0.1892 | 0.0000 | 0.6667 | 0.2914 | 0.6567 |