Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | GW843682X | PLK | PLK | 10581.139 | uM | inf | inf | 0.8086 | 0.8086 | 0.0000 | 0.1131 | 0.1274 | 1.1488 | |
| SUM229PE | TNBC | - | Cetuximab | EGFR | ErbB | 9860.125 | uM | inf | inf | 0.8773 | 0.8773 | 0.0000 | 0.0289 | 0.1275 | 1.6001 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7466.067 | uM | inf | inf | 0.9484 | 0.9484 | 0.0000 | -0.0204 | 0.1276 | 0.9457 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7547.072 | uM | inf | inf | 0.6965 | 0.6965 | 0.0000 | 0.2408 | -0.1290 | 0.8636 | |
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12291.169 | uM | inf | inf | 0.8955 | 0.8955 | 0.0000 | -0.0374 | 0.1290 | 0.3548 | ||
| Hs 578T | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7474.095 | uM | inf | inf | 0.8203 | 0.8203 | 0.0000 | 0.0493 | -0.1291 | 2.8423 | |
| MDA-MB-134-VI | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12206.161 | uM | inf | inf | 0.6658 | 0.6658 | 0.0000 | 0.0853 | 0.130 | 1.0580 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7475.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0020 | 0.1302 | 2.6839 | |
| AU565 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10880.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0108 | -0.1312 | 1.5205 | |
| HCC3153 | TNBC | Basal A | GM6001 | MMP | MMP | 7466.096 | uM | inf | inf | 0.8967 | 0.8967 | 0.0000 | 0.0827 | -0.1319 | 0.9269 | |
| SUM149PT | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13123.176 | uM | inf | inf | 0.6345 | 0.6345 | 0.0000 | 0.1874 | 0.1319 | 1.1020 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7835.018 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.8246 | 0.1320 | 0.5326 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7885.042 | uM | inf | inf | 1.0037 | 1.0037 | 0.0000 | 0.0264 | 0.1320 | 0.5912 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 9420.132 | uM | inf | inf | 0.4783 | 0.4783 | 0.0000 | 0.1427 | 0.1330 | 0.3309 | |
| AU565 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10880.149 | uM | inf | inf | 0.8678 | 0.8678 | 0.0000 | 0.0766 | 0.1343 | 1.6289 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 7900.012 | uM | inf | inf | 0.4439 | 0.4439 | 0.0000 | 0.5210 | -0.1349 | 0.8090 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7452.084 | uM | inf | inf | 0.9680 | 0.9680 | 0.0000 | -0.0014 | 0.1350 | 1.6800 | |
| MDA-MB-175-VII | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10642.144 | uM | inf | inf | 0.7684 | 0.7684 | 0.0000 | 0.1437 | 0.1354 | 0.6510 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5898.067 | uM | inf | inf | 0.8837 | 0.8837 | 0.0000 | 0.0867 | 0.1356 | 0.6532 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7877.042 | uM | inf | inf | 0.9001 | 0.9001 | 0.0000 | 0.0283 | 0.1356 | 0.3414 | |
| HCC1806 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7450.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0008 | 0.1356 | 1.0419 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7466.085 | uM | inf | inf | 0.9627 | 0.9627 | 0.0000 | 0.0395 | 0.1367 | 0.8684 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7453.098 | uM | inf | inf | 0.9252 | 0.9252 | 0.0000 | 0.0007 | 0.1372 | 1.4660 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 12224.155 | uM | inf | inf | 0.6879 | 0.6879 | 0.0000 | 0.1877 | 0.1373 | 1.0378 | |
| 600MPE | HR+ | Luminal | PD184352 | MEK | MAPK | 12224.155 | uM | inf | inf | 0.6879 | 0.6879 | 0.0000 | 0.1877 | 0.1373 | 1.0378 |