Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7435.098 | uM | inf | inf | 0.8541 | 0.8541 | 0.0000 | 0.1309 | 0.1162 | 0.7702 | |
| HCC70 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7470.095 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1485 | 0.1176 | 1.1893 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12056.154 | uM | inf | inf | 0.7002 | 0.7002 | 0.0000 | 0.2152 | -0.1183 | 0.9136 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| HCC2185 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7463.094 | uM | inf | inf | -0.9995 | -0.9995 | 0.0000 | 0.6783 | 0.1192 | 0.6482 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14293.189 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0506 | 0.1193 | 0.6707 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14293.189 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0506 | 0.1193 | 0.6707 | |
| HCC1937 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7453.095 | uM | inf | inf | 0.9591 | 0.9591 | 0.0000 | 0.0882 | 0.1205 | 1.6395 | |
| SUM185PE | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 12269.157 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1012 | 0.1215 | 0.5397 | |
| HCC1569 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9648 | 0.9648 | 0.0000 | 0.0039 | 0.1215 | 1.5288 | |
| MDA-MB-415 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10938.149 | uM | inf | inf | 0.8584 | 0.8584 | 0.0000 | 0.1758 | -0.1216 | 1.0006 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11938.16 | uM | inf | inf | 0.4474 | 0.4474 | 0.0000 | 0.2139 | 0.1216 | 0.6405 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12178.157 | uM | inf | inf | 0.8714 | 0.8714 | 0.0000 | -0.0235 | -0.1217 | 0.5528 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9536.006 | uM | inf | inf | 0.9716 | 0.9716 | 0.0000 | 0.0671 | 0.1220 | 1.2564 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 7872.017 | uM | inf | inf | 0.9560 | 0.9560 | 0.0000 | 0.0576 | 0.1221 | 1.5155 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 12523.155 | uM | inf | inf | 0.9460 | 0.9460 | 0.0000 | 0.0104 | 0.1224 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 12523.155 | uM | inf | inf | 0.9460 | 0.9460 | 0.0000 | 0.0104 | 0.1224 | 1.0583 | |
| CAMA-1 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12070.144 | uM | inf | inf | 0.8317 | 0.8317 | 0.0000 | 0.0762 | 0.1224 | 1.1742 | |
| UACC-812 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13078.176 | uM | inf | inf | 0.9053 | 0.9053 | 0.0000 | 0.0862 | -0.1229 | 0.7179 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12070.161 | uM | inf | inf | 0.8208 | 0.8208 | 0.0000 | 0.0972 | -0.1231 | 1.2903 | |
| SK-BR-3 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10127.123 | uM | inf | inf | 0.2747 | 0.2747 | 0.0000 | 0.4731 | 0.1249 | 0.8767 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7432.095 | uM | inf | inf | 1.0222 | 1.0222 | 0.0000 | 0.0161 | 0.1254 | 0.8368 | |
| UACC-812 | HER2amp | Luminal | Ro 32-0432 | PKC | PKC | 10580.142 | uM | inf | inf | 0.9492 | 0.9492 | 0.0000 | 0.0284 | 0.1268 | 0.8039 | |
| 600MPE | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12224.135 | uM | inf | inf | 0.7869 | 0.7869 | 0.0000 | 0.0993 | 0.1270 | 1.0314 |