Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 12523.168 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0083 | -0.040 | 0.9035 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 10996.149 | uM | inf | inf | 0.9724 | 0.9724 | 0.0000 | 0.0208 | 0.0401 | 0.4765 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 5902.098 | uM | inf | inf | 0.9860 | 0.9860 | 0.0000 | -0.0045 | -0.0403 | 1.1137 | |
| BT-20 | TNBC | Basal A | Pertuzumab | 5903.102 | mg/ml | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0074 | -0.0405 | 1.2557 | |||
| T47DKBLUC | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 7544.098 | uM | inf | inf | 0.9586 | 0.9586 | 0.0000 | 0.0541 | -0.0405 | 1.2438 | |
| T47DKBLUC | Unknown | Unknown | PD184352 | MEK | MAPK | 12608.155 | uM | inf | inf | 0.9291 | 0.9291 | 0.0000 | 0.0321 | 0.0410 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | PD184352 | MEK | MAPK | 12608.155 | uM | inf | inf | 0.9291 | 0.9291 | 0.0000 | 0.0321 | 0.0410 | 1.1556 | |
| SUM185PE | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 12269.154 | uM | inf | inf | 0.0944 | 0.0944 | 0.0000 | 0.3950 | 0.0416 | 0.9999 | |
| MDA-MB-134-VI | HR+ | Luminal | PD 98059 | MEK | MAPK | 10998.152 | uM | inf | inf | 0.7376 | 0.7376 | 0.0000 | 0.0782 | -0.0421 | 0.8517 | |
| MDA-MB-175-VII | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10818.148 | uM | inf | inf | 0.7403 | 0.7403 | 0.0000 | 0.1474 | -0.0425 | 0.3526 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 9386.132 | uM | inf | inf | 0.7520 | 0.7520 | 0.0000 | 0.1148 | 0.0425 | 1.4083 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10873.148 | uM | inf | inf | 0.9161 | 0.9161 | 0.0000 | 0.1719 | 0.0430 | 1.2150 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7898.018 | uM | inf | inf | 0.9583 | 0.9583 | 0.0000 | -0.0243 | -0.0431 | 1.1279 | |
| SUM185PE | TNBC | Luminal | Baicalein | Lipoxygenase | Metabolism | 12269.072 | uM | inf | inf | 0.6534 | 0.6534 | 0.0000 | 0.5211 | 0.0434 | 1.1256 | |
| SUM52PE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13570.176 | uM | inf | inf | 0.7219 | 0.7219 | 0.0000 | 0.3099 | 0.0434 | 0.4076 | |
| T47DKBLUC | Unknown | Unknown | 2-deoxyglucose | 13070.177 | uM | inf | inf | 0.0803 | 0.0803 | 0.0000 | 0.5360 | 0.0445 | 0.9040 | |||
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7905.018 | uM | inf | inf | 0.5870 | 0.5870 | 0.0000 | 0.1000 | -0.0447 | 0.8988 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 11851.155 | uM | inf | inf | 0.9361 | 0.9361 | 0.0000 | 0.0510 | 0.0449 | 1.5585 | |
| MCF 10F | NM | - | Baicalein | Lipoxygenase | Metabolism | 12254.072 | uM | inf | inf | 0.9615 | 0.9615 | 0.0000 | 0.0021 | 0.0460 | 1.9429 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9028.018 | uM | inf | inf | 0.8573 | 0.8573 | 0.0000 | 0.0500 | -0.0461 | 1.0242 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7447.066 | uM | inf | inf | 0.9240 | 0.9240 | 0.0000 | -0.0284 | 0.0463 | 1.5813 | |
| MCF 10A | NM | Basal B | PS-1145 | IKK | NFKB | 7485.065 | uM | inf | inf | 1.0111 | 1.0111 | 0.0000 | -0.0094 | -0.0465 | 3.5869 | |
| MDA-MB-134-VI | HR+ | Luminal | PS-1145 | IKK | NFKB | 10419.065 | uM | inf | inf | 1.0047 | 1.0047 | 0.0000 | 0.0356 | 0.0465 | 0.7359 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7905.016 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0810 | 0.0466 | 0.6240 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7454.065 | uM | inf | inf | 0.7779 | 0.7779 | 0.0000 | 0.1159 | 0.0469 | 1.0489 |