Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7492.095 | uM | inf | inf | 0.9180 | 0.9180 | 0.0000 | 0.0139 | 0.0229 | 1.0194 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7435.066 | uM | inf | inf | 0.8858 | 0.8858 | 0.0000 | 0.0656 | -0.0232 | 0.8924 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10127.123 | uM | inf | inf | 0.7010 | 0.7010 | 0.0000 | 0.1340 | 0.0237 | 0.8767 | |
| MDA-MB-361 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12379.17 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | -0.0239 | -0.0238 | 0.5805 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7473.091 | uM | inf | inf | 0.9017 | 0.9017 | 0.0000 | -0.0408 | -0.0238 | 2.3297 | |
| BT-483 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11855.135 | uM | inf | inf | 0.6973 | 0.6973 | 0.0000 | 0.1313 | -0.0247 | 0.6394 | |
| HCC38 | TNBC | Basal B | Ribavirin | 15351.211 | uM | inf | inf | 0.7443 | 0.7443 | 0.0000 | 0.0613 | -0.0247 | 1.0866 | |||
| AU565 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10880.145 | uM | inf | inf | 0.9804 | 0.9804 | 0.0000 | 0.0621 | 0.0247 | 1.4751 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7449.084 | uM | inf | inf | 0.9327 | 0.9327 | 0.0000 | 0.0427 | 0.0247 | 2.1410 | |
| HCC38 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10578.135 | uM | inf | inf | 0.9081 | 0.9081 | 0.0000 | 0.0395 | 0.0248 | 1.7650 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7465.095 | uM | inf | inf | 0.8393 | 0.8393 | 0.0000 | 0.1223 | -0.0252 | 1.2754 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| CAMA-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10755.152 | uM | inf | inf | 0.5641 | 0.5641 | 0.0000 | 0.2866 | -0.0260 | 0.5859 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13062.174 | uM | inf | inf | 0.9527 | 0.9527 | 0.0000 | 0.0333 | 0.0263 | 1.6688 | |
| UACC-893 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9953.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0816 | 0.0269 | 0.5411 | |
| HCC2185 | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 12192.154 | uM | inf | inf | 0.9309 | 0.9309 | 0.0000 | -0.0048 | -0.0270 | 0.5377 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7833.042 | uM | inf | inf | 0.8856 | 0.8856 | 0.0000 | 0.0972 | 0.0274 | 1.0332 | |
| MDA-MB-361 | HER2amp | Luminal | Nelfinavir | 13558.174 | uM | inf | inf | 0.7427 | 0.7427 | 0.0000 | 0.1261 | 0.0278 | 0.5699 | |||
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7837.042 | uM | inf | inf | 0.5276 | 0.5276 | 0.0000 | 0.1898 | -0.0281 | 1.6916 | |
| MDA-MB-361 | HER2amp | Luminal | GM6001 | MMP | MMP | 7506.096 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | 0.0173 | -0.0292 | 1.0303 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7515.065 | uM | inf | inf | 0.7626 | 0.7626 | 0.0000 | 0.1588 | 0.0295 | 1.3234 | |
| MDA-MB-415 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7510.098 | uM | inf | inf | 0.9619 | 0.9619 | 0.0000 | 0.0329 | -0.0298 | 0.9528 | |
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12070.145 | uM | inf | inf | 0.8990 | 0.8990 | 0.0000 | 0.1345 | 0.0301 | 1.0737 | |
| MDA-MB-157 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12632.176 | uM | inf | inf | 0.8532 | 0.8532 | 0.0000 | 0.0329 | 0.0301 | 0.8098 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5912.067 | uM | inf | inf | 0.8672 | 0.8672 | 0.0000 | 0.0876 | -0.0304 | 1.1725 |