Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12224.157 | uM | inf | inf | 0.6710 | 0.6710 | 0.0000 | 0.1152 | 0.3373 | 1.0737 | |
| 600MPE | HR+ | Luminal | Nilotinib | ABL | nRTK | 12224.145 | uM | inf | inf | 0.9894 | 0.9894 | 0.0000 | -0.0249 | -0.6099 | 0.9737 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5902.066 | uM | inf | inf | 0.9990 | 0.9990 | 0.0000 | -0.0235 | -0.9254 | 1.1775 | |
| AU565 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5900.085 | uM | inf | inf | 0.5199 | 0.5199 | 0.0000 | 0.0667 | 0.2964 | 2.6391 | |
| BT-20 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13579.176 | uM | inf | inf | 0.8837 | 0.8837 | 0.0000 | -0.0031 | 0.4777 | 0.7690 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7798.077 | uM | inf | inf | 0.8883 | 0.8883 | 0.0000 | -0.0257 | 0.4190 | 1.4371 | |
| 600MPE | HR+ | Luminal | GM6001 | MMP | MMP | 5898.096 | uM | inf | inf | 0.8794 | 0.8794 | 0.0000 | 0.0460 | -0.0341 | 0.6718 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12178.155 | uM | inf | inf | 0.7358 | 0.7358 | 0.0000 | 0.2219 | 0.0157 | 0.8489 | |
| 600MPE | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12224.154 | uM | inf | inf | 0.7982 | 0.7982 | 0.0000 | 0.0654 | 0.1825 | 0.9590 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13091.176 | uM | inf | inf | 0.9717 | 0.9717 | 0.0000 | 0.0439 | -0.10 | 0.8746 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5899.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0165 | 0.0780 | 0.7056 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12178.135 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | -0.0119 | 0.2808 | 0.5524 | |
| BT-474 | HER2amp | Luminal | GM6001 | MMP | MMP | 5905.096 | uM | inf | inf | 0.3979 | 0.3979 | 0.0000 | 0.1096 | 0.2122 | 0.9091 | |
| 184A1 | NM | Basal | Trastuzumab | HER2 | ErbB | 9047.026 | uM | inf | inf | 0.2837 | 0.2837 | 0.0000 | 0.2170 | 0.0804 | 0.5972 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 11854.135 | uM | inf | inf | 0.8384 | 0.8384 | 0.0000 | 0.0710 | 0.5319 | 1.3170 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9158.001 | uM | inf | inf | -0.9965 | -0.9965 | 0.0000 | 0.3194 | 0.2618 | 0.6988 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12056.154 | uM | inf | inf | 0.7002 | 0.7002 | 0.0000 | 0.2152 | -0.1183 | 0.9136 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7793.012 | uM | inf | inf | 1.0078 | 1.0078 | 0.0000 | -0.0215 | -0.0764 | 1.1030 | |
| 600MPE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5899.094 | uM | inf | inf | -0.9801 | -0.9801 | 0.0000 | 0.9711 | 0.3677 | 1.0334 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11854.155 | uM | inf | inf | 0.9135 | 0.9135 | 0.0000 | 0.0714 | 0.3056 | 1.3396 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 12224.072 | uM | inf | inf | 0.8349 | 0.8349 | 0.0000 | 0.1299 | -0.0188 | 1.0105 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 |