Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| LY2 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10816.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0123 | -0.0004 | 0.7766 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 5910.084 | uM | inf | inf | 0.9374 | 0.9374 | 0.0000 | -0.0121 | 0.4733 | 3.1096 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12178.135 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | -0.0119 | 0.2808 | 0.5524 | |
| SUM225CWN | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 10579.144 | uM | inf | inf | 0.8597 | 0.8597 | 0.0000 | -0.0118 | 0.3052 | 0.9576 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7474.074 | uM | inf | 3.54150 | 0.8416 | 0.8448 | 4.9283 | -0.0117 | 0.7209 | 2.6218 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9997.026 | uM | 10.14060 | 9.03470 | 0.8100 | 0.2193 | 4.9983 | -0.0116 | 0.7236 | 1.1348 | |
| Hs 578T | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7474.069 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0115 | -0.0565 | 2.5606 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7473.098 | uM | inf | inf | 0.7393 | 0.7393 | 0.0000 | -0.0112 | 0.2240 | 2.2810 | |
| MCF12A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 10817.154 | uM | inf | inf | 1.0326 | 1.0326 | 0.0000 | -0.0111 | -0.1985 | 1.4551 | |
| LY2 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10816.144 | uM | inf | inf | 0.9453 | 0.9453 | 0.0000 | -0.0111 | -0.0185 | 0.9146 | |
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7473.084 | uM | 1210.01560 | 999.18010 | 0.6509 | 0.3033 | 4.8722 | -0.0111 | 0.8989 | 2.0337 | |
| MCF 10A | NM | Basal B | Trastuzumab | HER2 | ErbB | 9551.026 | uM | inf | inf | 0.9124 | 0.9124 | 0.0000 | -0.0111 | 0.4645 | 2.6508 | |
| ZR-75-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7931.042 | uM | inf | inf | 0.8278 | 0.8278 | 0.0000 | -0.0111 | 0.4074 | 1.3878 | |
| T47DKBLUC | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7545.092 | uM | inf | inf | 0.9211 | 0.9211 | 0.0000 | -0.0109 | 0.4842 | 0.9794 | |
| AU565 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10880.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0108 | -0.1312 | 1.5205 | |
| MCF12A | NM | Basal B | Trastuzumab | HER2 | ErbB | 10061.123 | uM | 17.14380 | 8.78160 | 0.8599 | 0.4824 | 4.9997 | -0.0107 | 0.7497 | 1.9064 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9723.049 | uM | inf | inf | 1.0150 | 1.0150 | 0.0000 | -0.0107 | -0.0715 | 0.9525 | |
| MDA-MB-361 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 7506.093 | uM | inf | inf | 0.7940 | 0.7940 | 0.0000 | -0.0107 | 0.1828 | 0.9162 | |
| HCC3153 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 10577.137 | uM | inf | inf | 0.9341 | 0.9341 | 0.0000 | -0.0104 | 0.0824 | 0.9653 | |
| MCF 10F | NM | - | (Z)-4-Hydroxytamoxifen | ESR1 | 7871.016 | uM | inf | 34.66260 | 0.8429 | 0.8429 | 4.9988 | -0.0104 | 0.6376 | 1.0272 | ||
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7466.095 | uM | inf | inf | 1.0039 | 1.0039 | 0.0000 | -0.0104 | -0.0877 | 0.8699 | |
| HCC1395 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7816.042 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | -0.0101 | -0.0006 | 0.9332 | |
| Hs 578T | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12622.176 | uM | inf | inf | 0.9947 | 0.9947 | 0.0000 | -0.0101 | -0.9347 | 2.5005 |