Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7442.085 | uM | 0.00643 | 0.01886 | -0.9964 | -1.0000 | 1.0202 | 1.1658 | 0.9946 | 0.8237 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14909.203 | uM | 0.01538 | 0.01897 | -0.9320 | -0.9266 | 4.9991 | 1.2416 | 0.9995 | 1.3791 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14909.203 | uM | 0.01538 | 0.01897 | -0.9320 | -0.9266 | 4.9991 | 1.2416 | 0.9995 | 1.3791 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 9118.012 | uM | 0.03583 | 0.01918 | 0.2517 | 0.2591 | 1.1692 | 0.3787 | 0.9783 | 1.0154 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9997.011 | uM | 0.03217 | 0.01921 | 0.4132 | 0.4620 | 4.9943 | 0.3567 | 0.9393 | 1.0551 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7435.067 | uM | 0.01113 | 0.01926 | -0.9999 | -0.7978 | 1.7403 | 1.0215 | 0.9797 | 0.7691 | |
| Hs 578T | TNBC | Basal B | Trametinib | MEK | MAPK | 7862.036 | uM | 0.01585 | 0.01929 | -0.3313 | -0.2156 | 1.8220 | 0.6474 | 0.9710 | 1.2405 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9953.037 | uM | 0.01002 | 0.01932 | -0.9981 | -0.9490 | 1.6193 | 1.2817 | 0.9974 | 0.4884 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10127.001 | uM | 0.01904 | 0.01938 | -0.9787 | -0.0461 | 4.9630 | 0.5228 | 0.5961 | 0.8568 | |
| BT-483 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9186.002 | uM | 0.02228 | 0.01940 | 0.0839 | 0.1113 | 1.8218 | 0.4052 | 0.9887 | 0.4768 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 9723.002 | uM | 0.01302 | 0.01943 | -0.4095 | -0.4017 | 1.4740 | 0.8003 | 0.9958 | 0.8443 | |
| MDA-MB-175-VII | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 7886.04 | uM | 0.01509 | 0.01945 | -0.5854 | -0.5556 | 2.9455 | 1.0357 | 0.9980 | 0.7771 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7898.001 | uM | 0.01767 | 0.01948 | -0.2097 | -0.1217 | 2.2342 | 0.6544 | 0.9777 | 1.2337 | |
| HCC3153 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7853.011 | uM | inf | 0.01974 | 0.5123 | 0.5486 | 3.3194 | 0.3149 | 0.9622 | 1.6331 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 7873.04 | uM | 0.01582 | 0.01976 | -0.5192 | -0.4643 | 2.9510 | 0.9705 | 0.9971 | 2.1738 | |
| MDA-MB-175-VII | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12126.158 | uM | 0.00446 | 0.01986 | -0.9994 | -1.0000 | 0.7352 | 1.3131 | 0.8929 | 0.5992 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7864.001 | uM | 0.01895 | 0.01995 | -0.3195 | -0.0856 | 3.0653 | 0.6294 | 0.9358 | 1.4976 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7553.086 | uM | 0.00624 | 0.01999 | -0.7384 | -0.6927 | 0.7464 | 0.9756 | 0.9947 | 1.0750 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7812.001 | uM | 0.01826 | 0.02012 | -0.0998 | -0.2890 | 4.7105 | 0.7349 | 0.8631 | 1.0060 | |
| SUM159PT | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7531.086 | uM | 0.02036 | 0.02017 | -0.0133 | 0.0051 | 1.1296 | 0.5707 | 0.9982 | 3.3103 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7545.095 | uM | 0.00970 | 0.02021 | -0.9795 | -0.3082 | 0.6544 | 0.7119 | 0.7269 | 1.0123 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 7839.05 | uM | 0.76028 | 0.02032 | 0.4491 | 0.4606 | 0.7011 | 0.2914 | 0.8467 | 1.7470 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7920.05 | uM | inf | 0.02034 | 0.4715 | 0.5077 | 0.6584 | 0.2518 | 0.9823 | 4.1624 | |
| SUM229PE | TNBC | - | Taxol | TUBB | TUBB | 13009.002 | uM | 0.01925 | 0.02034 | -0.0938 | -0.0708 | 2.3909 | 0.6076 | 0.9968 | 1.3417 | |
| HCC1187 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7811.001 | uM | 0.01688 | 0.02037 | -0.7570 | -0.7774 | 5.0000 | 1.0477 | 0.9812 | 0.4464 |