Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Torkinib | 15355.211 | uM | 0.00026 | 0.00531 | -0.8198 | -0.8282 | 0.3225 | 1.2019 | 0.9869 | 1.0584 | |||
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 14807.203 | uM | 0.00365 | 0.00535 | -0.7798 | -0.7104 | 2.3037 | 1.2491 | 0.9925 | 1.7148 | |
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 9536.012 | uM | inf | 0.00536 | 0.8520 | 0.8999 | 4.9998 | 0.0482 | 0.7947 | 1.4096 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9536.002 | uM | 0.00418 | 0.00548 | -0.2397 | -0.2457 | 1.4695 | 0.7191 | 0.9989 | 1.3627 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7899.001 | uM | 0.02210 | 0.00549 | 0.3607 | 0.4166 | 1.2863 | 0.3825 | 0.9565 | 2.0444 | |
| MCF12A | NM | Basal B | Docetaxel | TUBB | TUBB | 10061.002 | uM | 0.03596 | 0.00551 | 0.4666 | 0.4502 | 1.2301 | 0.3153 | 0.9765 | 1.8759 | |
| BT-549 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10261.002 | uM | 0.00660 | 0.00553 | 0.1803 | 0.1400 | 1.8504 | 0.4965 | 0.9808 | 2.1983 | |
| HCC38 | TNBC | Basal B | Topotecan | TOP1 | TOP | 10268.007 | uM | 0.00355 | 0.00556 | -0.7595 | -0.6170 | 1.7917 | 1.2327 | 0.8728 | 1.3306 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7811.002 | uM | 0.00284 | 0.00560 | -0.9883 | -0.9948 | 1.6129 | 1.1674 | 0.9996 | 0.4929 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7814.042 | uM | 0.00326 | 0.00560 | -0.9897 | -0.8260 | 1.8086 | 1.2937 | 0.9791 | 0.8414 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7468.095 | uM | 0.00356 | 0.00561 | -0.9857 | -0.5908 | 1.7194 | 1.0633 | 0.9517 | 1.4474 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9028.075 | uM | 0.00457 | 0.00564 | -0.9576 | -0.9350 | 5.0000 | 1.7932 | 0.9991 | 0.6011 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.011 | uM | 0.00436 | 0.00565 | -0.7427 | -0.6976 | 3.3673 | 1.3528 | 0.9958 | 1.1991 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7813.002 | uM | 0.00427 | 0.00565 | -0.3992 | -0.3837 | 2.0301 | 0.8129 | 0.9487 | 0.8463 | |
| BT-549 | TNBC | Basal B | Taxol | TUBB | TUBB | 12690.002 | uM | 0.00580 | 0.00565 | -0.0151 | 0.0286 | 2.2660 | 0.6572 | 0.9920 | 2.4397 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10267.002 | uM | 0.00511 | 0.00565 | -0.4735 | -0.3262 | 5.0000 | 0.8803 | 0.9892 | 0.4069 | |
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9648.002 | uM | 0.00471 | 0.00566 | -0.2165 | -0.2169 | 1.9624 | 0.7100 | 0.9654 | 0.6465 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7437.086 | uM | 0.0020 | 0.00570 | -0.9790 | -0.8720 | 0.9632 | 1.2599 | 0.9859 | 0.4150 | |
| 184B5 | NM | Basal | Sirolimus | MTOR | MTOR | 5896.069 | uM | inf | 0.00571 | 0.7756 | 0.7626 | 1.4422 | 0.1582 | 0.9050 | 1.5507 | |
| HCC2185 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7845.018 | uM | 0.00524 | 0.00571 | -0.9983 | -0.2362 | 4.5293 | 0.7980 | 0.7029 | 0.4518 | |
| HCC1143 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7809.068 | uM | 1.18010 | 0.00577 | 0.3535 | 0.3928 | 0.2895 | 0.4238 | 0.7314 | 1.7208 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7833.001 | uM | 0.00335 | 0.00581 | -0.2423 | -0.1358 | 0.4379 | 0.7376 | 0.8118 | 1.0468 | |
| HCC70 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 9501.002 | uM | 0.00302 | 0.00582 | -0.5255 | -0.5680 | 1.1563 | 0.9048 | 0.9833 | 1.0082 | |
| MDA-MB-453 | TNBC | Luminal | Torkinib | 15398.211 | uM | 0.00074 | 0.00583 | -0.5991 | -0.5679 | 0.3671 | 1.0368 | 0.9859 | 1.0628 |