Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
184A1
NM
Basal
 GSK1838705A
IGF1R
RTK
5895.098
uM
0.42849
0.39937
 0.0166 0.0538 1.6165 0.3574
0.9937
 1.4041
184A1
NM
Basal
 GSK1838705A
IGF1R
RTK
5894.098
uM
0.36902
0.35227
 0.0333 0.0487 2.2061 0.3782
0.9970
 1.6523
184A1
NM
Basal
 GSK461364
PLK1
PLK
9047.001
uM
4.15810
52.44110
 -0.0073 -1.0000 0.4334 0.2620
0.7464
 0.7701
184A1
NM
Basal
 GSK461364
PLK1
PLK
10002.001
uM
6.06620
9.11620
 -0.9717 -1.0000 2.6972 0.2605
0.9735
 0.5372
184A1
NM
Basal
 GSK923295
CENPE
Kinesin
9047.001
uM
inf
inf
 0.0385 0.0385 0.0000 0.2510
0.5226
 0.7701
184A1
NM
Basal
 GSK923295
CENPE
Kinesin
10002.001
uM
8.47170
11.6240
 -0.9507 -1.0000 3.4729 0.2407
0.9439
 0.5372
184A1
NM
Basal
 GW-5074
CRAF
MAPK
5895.088
uM
2.20640
4.30790
 -0.5359 -0.6571 1.2540 0.2508
0.9932
 1.3297
184A1
NM
Basal
 Ibandronate
FDPS
12509.143
uM
155.22840
288.34070
 -0.9140 -1.0000 1.7741 0.2785
0.9964
 1.3392
184A1
NM
Basal
 ICRF-193
TOP2
TOP
12509.157
uM
inf
0.17119
 0.6433 0.6783 0.6598 0.1328
0.9202
 1.2837
184A1
NM
Basal
 IKK16
IKK
NFKB
5895.093
uM
1.01110
2.37210
 -0.9564 -1.0000 1.2884 0.5085
0.9882
 1.3259
184A1
NM
Basal
 Imatinib
ABL/KIT/PDGFR
nRTK
5895.091
uM
16.09010
26.49230
 -0.9899 -1.0000 2.2032 0.4630
0.9969
 1.1729
184A1
NM
Basal
 Ispinesib
KSP
Kinesin
5894.067
uM
1.62180
3.48940
 -0.9288 -1.0000 1.4339 0.3983
0.9581
 1.5647
184A1
NM
Basal
 JNK-IN-5A
JNK
JNK
12509.168
uM
inf
0.95387
 0.3859 0.6171 4.9990 0.1487
0.7274
 1.3516
184A1
NM
Basal
 Ixabepilone
TUBB
TUBB
5894.095
uM
0.46640
0.69919
 -0.9010 -0.8976 2.5388 0.6159
0.9985
 1.7133
184A1
NM
Basal
 Doxorubicin
TOP2
TOP
10002.034
uM
0.10668
0.20741
 -1.0000 -0.9682 1.6201 0.9516
0.9936
 0.6736
184A1
NM
Basal
 Ixabepilone
TUBB
TUBB
5895.095
uM
0.14338
0.76637
 -0.9501 -1.0000 0.6554 0.6829
0.9483
 1.4629
184A1
NM
Basal
 L-779450
BRAF
MAPK
12509.166
uM
8.56520
14.40640
 -0.7107 -1.0000 2.1129 0.1672
0.9687
 1.2847
184A1
NM
Basal
 Lapatinib
EGFR/HER2
ErbB
5895.098
uM
1.84620
1.07940
 0.2337 0.4659 5.0000 0.0845
0.8011
 1.4041
184A1
NM
Basal
 Lapatinib
EGFR/HER2
ErbB
5894.098
uM
1.96260
1.83210
 0.0794 0.0736 2.3169 0.1499
0.9957
 1.6523
184A1
NM
Basal
 LBH589
HDAC
HDAC
12509.167
uM
0.29923
0.89089
 -0.7415 -0.8021 0.8773 0.4884
0.9905
 1.4256
184A1
NM
Basal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12509.167
uM
1.46780
2.26520
 -0.8669 -0.8656 2.3156 0.3809
0.9959
 1.4256
184A1
NM
Basal
 Mebendazole
12684.174
uM
inf
0.36667
 0.5334 0.5745 5.0000 0.1723
0.9699
 1.4645
184A1
NM
Basal
 Methotrexate
DHFR
Metabolism
5894.084
uM
0.05840
0.06456
 -0.2992 -0.3127 4.8467 0.9024
0.9966
 1.5903
184A1
NM
Basal
 Ispinesib
KSP
Kinesin
5895.067
uM
2.25070
4.57410
 -0.9091 -1.0000 1.5491 0.3497
0.9692
 1.4053
184A1
NM
Basal
 Doxorubicin
TOP2
TOP
9047.121
uM
0.13985
0.26689
 -0.9987 -0.9310 1.6271 0.9214
0.9807
 0.7949