Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21NT | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14610.189 | uM | 0.28136 | 0.47547 | -0.9402 | -0.9548 | 2.0356 | 0.7876 | 0.9958 | 1.0787 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| AU565 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10880.152 | uM | 0.28434 | 0.39562 | -0.9128 | -0.9095 | 3.1379 | 0.6283 | 0.9992 | 1.5019 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10880.148 | uM | 92.11310 | 64.4710 | 0.5895 | 0.1992 | 1.4239 | 0.0656 | 0.8672 | 1.7293 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9035.077 | uM | 0.01867 | 0.02396 | -0.4295 | -0.3234 | 1.9985 | 0.8566 | 0.9892 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9146.121 | uM | 0.01728 | 0.02395 | -0.7986 | -0.7069 | 2.6999 | 1.1222 | 0.9930 | 1.1366 | |
| AU565 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10880.15 | uM | 2.73850 | 28.8840 | -0.0910 | -1.0000 | 0.4663 | 0.2379 | 0.9607 | 1.5829 | |
| AU565 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 5900.093 | uM | inf | 0.93328 | 0.7314 | 0.7514 | 2.1906 | 0.0802 | 0.9857 | 2.3084 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7793.036 | uM | 14.51550 | 16.41960 | 0.2574 | -0.4247 | 4.9882 | 0.0334 | 0.9587 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9146.122 | uM | inf | 0.00184 | 0.5003 | 0.6442 | 5.0000 | 0.2137 | 0.8848 | 1.3408 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7794.018 | uM | 0.02686 | 0.03077 | -0.6721 | -0.4598 | 4.8063 | 0.7843 | 0.9718 | 1.6812 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9035.018 | uM | 0.00465 | 0.00516 | -0.4202 | -0.3390 | 5.0000 | 0.9224 | 0.9868 | 2.1555 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5901.065 | uM | 88.2550 | 141.19540 | -0.8560 | -0.8531 | 2.1186 | 0.7219 | 0.9986 | 2.0114 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5900.065 | uM | 97.10380 | 150.36460 | -0.8266 | -0.8361 | 2.2478 | 0.6955 | 0.9992 | 2.2026 | |
| AU565 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14113.189 | uM | 0.67853 | 0.82980 | -0.8637 | -0.8677 | 5.0000 | 0.6309 | 0.9970 | 1.4645 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10880.15 | uM | inf | 0.49203 | 0.4211 | 0.5508 | 2.4406 | 0.1717 | 0.8585 | 1.5829 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9158.037 | uM | 0.01213 | 0.01343 | -0.1754 | -0.3299 | 4.9817 | 0.9735 | 0.6470 | 0.4702 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9163.037 | uM | 0.02296 | 0.02797 | -0.9651 | -0.8419 | 4.9994 | 1.1656 | 0.9949 | 0.5258 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12291.143 | uM | 252.60420 | 1000.00000 | -0.2515 | -0.6987 | 0.6355 | 0.3058 | 0.9375 | 0.5621 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7798.017 | uM | 688.02420 | 1000.00000 | -0.1296 | -0.1902 | 0.8622 | 0.2785 | 0.9937 | 1.4161 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12291.165 | uM | 0.00084 | 0.00487 | -0.9997 | -1.0000 | 0.6233 | 1.4610 | 0.9623 | 0.5602 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12056.158 | uM | 0.00506 | 0.01885 | -0.9829 | -0.8526 | 0.7565 | 1.1618 | 0.9747 | 0.9929 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5906.091 | uM | 51.04090 | 63.58320 | -0.9920 | -1.0000 | 5.0000 | 0.0972 | 0.9943 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5906.098 | uM | 269.90540 | 69.67660 | 0.7098 | 0.4039 | 1.2174 | 0.0195 | 0.8443 | 0.8050 |