Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10019.124 | uM | 6.80690 | 30.23160 | -0.9945 | -1.0000 | 0.7369 | 0.5217 | 0.9114 | 0.5356 | ||
| HCC1419 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10019.124 | uM | 8.22850 | 7.66340 | 0.6382 | 0.1473 | 4.9063 | 0.0323 | 0.6853 | 0.5356 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10019.124 | uM | inf | inf | 0.9810 | 0.9810 | 0.0000 | -0.0457 | -3.7312 | 0.5356 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10031.001 | uM | 7.23950 | 9.99140 | -0.9807 | -1.0000 | 3.4100 | 0.2079 | 0.980 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10031.001 | uM | 8.70410 | 17.26910 | -0.4989 | -1.0000 | 1.6035 | 0.2417 | 0.8704 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 10031.001 | uM | 6.51590 | 11.98480 | -0.7686 | -1.0000 | 1.8028 | 0.2433 | 0.9591 | 0.8981 | |
| HCC1428 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10031.002 | uM | inf | 0.01129 | 0.5669 | 0.5754 | 1.0719 | 0.2081 | 0.9236 | 0.6483 | |
| HCC1428 | HR+ | Luminal | Taxol | TUBB | TUBB | 10031.002 | uM | inf | 0.01672 | 0.4898 | 0.5157 | 1.5331 | 0.2758 | 0.9802 | 0.6483 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 10031.012 | uM | inf | inf | 0.5863 | 0.5863 | 0.0000 | 0.0897 | 0.2387 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 10031.012 | uM | 0.02610 | 0.02690 | -0.1006 | -0.0817 | 4.9980 | 0.6907 | 0.9950 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10031.021 | uM | 44.39150 | 54.72210 | -0.9223 | -0.9233 | 5.0000 | 0.2206 | 0.9924 | 0.8450 | |
| HCC1428 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10031.021 | uM | 135.23960 | 237.17580 | -0.8861 | -0.9550 | 1.9014 | 0.2373 | 0.9966 | 0.8450 | |
| HCC1428 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10031.021 | uM | 7.36630 | 10.97360 | -0.9589 | -0.9436 | 2.6602 | 0.6062 | 0.9980 | 0.8450 | |
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10031.034 | uM | 180.63980 | 547.45130 | -0.9933 | -1.0000 | 0.9908 | 0.4737 | 0.9029 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10031.034 | uM | 1.05840 | 1.42520 | -0.9868 | -0.9247 | 3.5196 | 0.5885 | 0.9979 | 0.8064 | |
| HCC1428 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 10031.034 | uM | 21.88210 | 39.25110 | -0.5356 | -1.0000 | 1.8802 | 0.1098 | 0.9914 | 0.8064 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 10056.001 | uM | 0.06152 | 0.06779 | -0.1880 | -0.1777 | 3.1365 | 0.5741 | 0.9955 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 10056.001 | uM | 0.01507 | 0.01546 | -0.4012 | -0.0660 | 4.9405 | 0.5985 | 0.9322 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10056.001 | uM | 12.78590 | 52.63390 | 0.1678 | -1.0000 | 0.7764 | 0.1357 | 0.9744 | 0.9052 | |
| HCC3153 | TNBC | Basal A | Taxol | TUBB | TUBB | 10056.002 | uM | 0.01766 | 0.02353 | -0.4734 | -0.4586 | 2.2671 | 0.8140 | 0.9985 | 0.8731 | |
| HCC3153 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 10056.002 | uM | 0.00969 | 0.01441 | -0.4252 | -0.4180 | 1.5338 | 0.7117 | 0.9956 | 0.8731 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 10056.012 | uM | inf | 1000.00000 | 0.7725 | -0.2424 | 0.4004 | 0.0559 | 0.6645 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 10056.012 | uM | 0.07489 | 0.10209 | -0.4085 | -0.3544 | 1.7290 | 0.7231 | 0.9966 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10056.021 | uM | 5.58260 | 20.4540 | -0.9069 | -1.0000 | 0.8461 | 0.5723 | 0.9822 | 0.8839 | |
| HCC3153 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 10056.021 | uM | 46.19960 | 55.15930 | -0.8595 | -0.7128 | 4.9990 | 0.4907 | 0.9762 | 0.8839 |