Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10151.034 | uM | 0.04740 | 0.10608 | -1.0000 | -1.0000 | 1.3638 | 1.0938 | 0.9616 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10151.034 | uM | 2.18960 | 2.47240 | -0.6914 | -0.4143 | 4.9682 | 0.3383 | 0.9554 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10151.034 | uM | 2.57870 | 64.17660 | -1.0000 | -1.0000 | 0.3418 | 0.7599 | 0.7768 | 0.3226 | ||
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 10261.001 | uM | 3.66530 | 7.32490 | -0.9301 | -1.0000 | 1.5867 | 0.2924 | 0.9804 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10261.001 | uM | 0.06157 | 0.15170 | -0.4222 | -0.4109 | 0.6651 | 0.5699 | 0.9713 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 10261.001 | uM | 0.05714 | 0.05080 | 0.2077 | 0.2224 | 4.9999 | 0.3810 | 0.9940 | 2.3472 | |
| BT-549 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10261.002 | uM | 0.00660 | 0.00553 | 0.1803 | 0.1400 | 1.8504 | 0.4965 | 0.9808 | 2.1983 | |
| BT-549 | TNBC | Basal B | Taxol | TUBB | TUBB | 10261.002 | uM | 0.01012 | 0.00927 | 0.0166 | 0.1038 | 2.6731 | 0.5610 | 0.9897 | 2.1983 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.011 | uM | 0.01194 | 0.01438 | -0.1730 | -0.1227 | 1.1802 | 0.7950 | 0.9945 | 2.4327 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10261.011 | uM | 20.3880 | 32.63670 | -0.4246 | -0.4607 | 1.3880 | 0.4313 | 0.9983 | 2.4327 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10261.011 | uM | 3.26910 | 29.80390 | -0.7067 | -1.0000 | 0.4971 | 0.5294 | 0.9547 | 2.4327 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 10261.024 | uM | 0.00607 | 0.00648 | -0.1576 | -0.1944 | 5.0000 | 0.8906 | 0.9943 | 2.1838 | |
| BT-549 | TNBC | Basal B | Trametinib | MEK | MAPK | 10261.024 | uM | inf | 0.07036 | 0.5537 | 0.5551 | 0.7972 | 0.1822 | 0.9709 | 2.1838 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 10261.024 | uM | inf | inf | 0.2887 | 0.2887 | 0.0000 | 0.2246 | 0.0877 | 2.1838 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10261.026 | uM | inf | inf | 0.9943 | 0.9943 | 0.0000 | -0.0202 | -1.1867 | 2.4866 | |
| BT-549 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10261.026 | uM | inf | 7.81790 | 0.8340 | 0.5838 | 4.9972 | -0.0048 | 0.8731 | 2.4866 | |
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10261.026 | uM | 64.76250 | 644.36690 | -0.7483 | -1.0000 | 0.4782 | 0.4717 | 0.8595 | 2.4866 | ||
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 10261.037 | uM | 0.02633 | 0.02899 | -0.7748 | -0.3082 | 5.0000 | 0.7926 | 0.9233 | 2.1973 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 10261.121 | uM | 4.34150 | 11.72620 | -0.6572 | -0.8745 | 1.0178 | 0.3079 | 0.9985 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10261.121 | uM | 0.12617 | 0.30282 | -0.8923 | -0.7083 | 1.0077 | 0.7467 | 0.9653 | 2.2540 | |
| BT-549 | TNBC | Basal B | Topotecan | TOP1 | TOP | 10261.121 | uM | 0.02045 | 0.03116 | -0.3874 | -0.4135 | 1.4319 | 0.8920 | 0.9807 | 2.2540 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.131 | uM | -inf | 0.00002 | -0.3245 | -0.3912 | 0.1000 | 1.0766 | 0.7849 | 2.3992 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 10261.131 | uM | 215.57540 | 290.46960 | -0.0136 | -0.0848 | 0.5253 | 0.3560 | 0.9881 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10261.131 | uM | 1.98770 | 3.79980 | -0.5492 | -0.5789 | 1.1869 | 0.5255 | 0.9939 | 2.3992 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 10262.001 | uM | 0.02489 | 0.02384 | -0.1295 | 0.0319 | 1.5210 | 0.5180 | 0.9664 | 0.6105 |