Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9035.001 | uM | 0.02298 | 0.02665 | -0.0875 | -0.2211 | 2.4716 | 0.6936 | 0.9681 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7793.001 | uM | 0.02405 | 0.02845 | -0.7415 | -0.6582 | 5.0000 | 0.9064 | 0.9803 | 1.1508 | |
| AU565 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 5900.088 | uM | inf | 7.75810 | 0.6475 | 0.6473 | 4.9899 | 0.0383 | 0.9887 | 2.7830 | |
| AU565 | HER2amp | Luminal | Ibandronate | FDPS | 10880.143 | uM | 190.49250 | 139.95740 | 0.2035 | 0.1860 | 1.5087 | 0.1480 | 0.9763 | 1.6077 | ||
| AU565 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10880.151 | uM | 1.03060 | 0.48809 | 0.2691 | 0.2426 | 0.8883 | 0.2612 | 0.9893 | 1.8509 | |
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 5900.093 | uM | 3.11010 | 4.89820 | -0.7771 | -0.7902 | 2.0869 | 0.3658 | 0.9980 | 2.3084 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5901.091 | uM | 19.04840 | 28.45990 | -0.8741 | -0.8850 | 2.5375 | 0.4460 | 0.9984 | 1.9229 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5900.092 | uM | 25.17290 | 35.4570 | -0.7508 | -0.7538 | 2.6838 | 0.3679 | 0.9995 | 2.6334 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5900.067 | uM | 0.02287 | 0.02721 | -0.8045 | -0.5292 | 4.1590 | 0.8231 | 0.9793 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5901.067 | uM | 0.01802 | 0.02217 | -0.9025 | -0.7242 | 4.3172 | 0.9599 | 0.9934 | 1.8762 | |
| 600MPE | HR+ | Luminal | Ibandronate | FDPS | 12224.143 | uM | 126.68820 | 145.52130 | -0.4151 | -0.4152 | 4.3619 | 0.2882 | 0.9949 | 0.8349 | ||
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 5898.088 | uM | inf | inf | 0.8157 | 0.8157 | 0.0000 | 0.0414 | -0.0040 | 0.6095 | |
| 184B5 | NM | Basal | GSK1070916 | AURK | AURK | 9095.001 | uM | 0.66025 | 4.63870 | -0.5752 | -1.0000 | 0.5635 | 0.3925 | 0.9830 | 1.0444 | |
| 184A1 | NM | Basal | Omipalisib | PI3K | PI3K | 5895.086 | uM | 0.00183 | 0.00262 | -0.5032 | -0.1746 | 0.8363 | 0.8309 | 0.9163 | 1.2802 | |
| 184A1 | NM | Basal | Gefitinib | EGFR | ErbB | 9047.132 | uM | inf | inf | 0.4414 | 0.4414 | 0.0000 | 0.4398 | 0.3588 | 0.6985 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9118.001 | uM | inf | inf | 0.5960 | 0.5960 | 0.0000 | 0.1146 | 0.4985 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9120.001 | uM | inf | inf | 0.4795 | 0.4795 | 0.0000 | 0.1244 | 0.2915 | 0.6180 | |
| 184B5 | NM | Basal | GM6001 | MMP | MMP | 5897.096 | uM | inf | inf | 0.9590 | 0.9590 | 0.0000 | 0.0206 | -0.0228 | 1.2810 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9120.001 | uM | 10.38820 | 12.94090 | -0.9973 | -1.0000 | 5.0000 | 0.2756 | 0.7682 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9118.001 | uM | 10.85090 | 4.85940 | 0.4914 | 0.4910 | 4.9999 | 0.1089 | 0.7439 | 1.0946 | |
| 184B5 | NM | Basal | Glycyl-H-1152 | ROCK2 | 12566.169 | uM | 211.26010 | 999.92730 | 0.5910 | -0.3569 | 0.3465 | 0.1053 | 0.8971 | 1.6359 | ||
| 184A1 | NM | Basal | Olomoucine II | CDK1 | CDK | 12509.147 | uM | 3.35230 | 4.08990 | -0.3436 | -0.3230 | 2.5061 | 0.3311 | 0.9956 | 1.2058 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.07 | uM | 0.22856 | 0.81326 | -0.9610 | -1.0000 | 0.8656 | 0.6820 | 0.9966 | 0.8850 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.09 | uM | 0.45454 | 0.39719 | 0.1073 | 0.1332 | 2.2958 | 0.4063 | 0.9921 | 1.0401 | |
| 184B5 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 9095.119 | uM | 0.39268 | 1000.00000 | -0.4244 | -0.9804 | 0.1384 | 0.6890 | 0.7465 | 1.2263 |