Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	Purvalanol A	CDK1	CDK	5895.067	uM	51.18430	39.92310	0.3558	0.3553	4.9894	0.0457	0.9764	1.4053
184A1	NM	Basal	GSK1070916	AURK	AURK	9047.001	uM	0.83697	5.25260	-0.4457	-0.9735	0.5885	0.3812	0.9828	0.7701
184B5	NM	Basal	Methotrexate	DHFR	Metabolism	5897.085	uM	0.04372	0.05133	-0.6179	-0.6153	5.0000	1.1076	0.9993	1.2392
184B5	NM	Basal	Methotrexate	DHFR	Metabolism	5896.084	uM	0.02683	0.03281	-0.4711	-0.4849	3.3686	1.0619	0.9980	1.5200
184A1	NM	Basal	PS-1145	IKK	NFKB	5894.065	uM	inf	416.61250	0.8384	0.8383	4.9997	-0.0087	0.7490	1.6064
184B5	NM	Basal	Mebendazole			12979.174	uM	inf	0.50538	0.5338	0.6450	4.9853	0.1589	0.6593	1.5680
184B5	NM	Basal	Lestaurtinib	FLT3/JAK2/TrkA	RTK	12566.167	uM	0.40063	1.20680	-0.8855	-1.0000	0.9963	0.5481	0.9929	1.5941
184A1	NM	Basal	PS-1145	IKK	NFKB	5895.065	uM	inf	inf	1.0031	1.0031	0.0000	-0.0389	-4.6402	1.3748
184A1	NM	Basal	GM6001	MMP	MMP	5895.096	uM	inf	inf	0.9763	0.9763	0.0000	-0.0141	-0.1057	1.4232
184A1	NM	Basal	CPT-11	TOP1	TOP	9047.121	uM	3.33380	6.76440	-0.6694	-0.7837	1.3326	0.4789	0.9103	0.7949
184A1	NM	Basal	Bortezomib	Proteasome	Proteasome	5894.074	uM	0.03715	0.13270	-0.6899	-0.6765	0.6722	0.9059	0.9559	1.4541
184A1	NM	Basal	AG1024	IGF1R	RTK	5894.066	uM	0.20895	0.19857	0.0442	0.1124	5.0000	0.3444	0.9895	1.5027
184A1	NM	Basal	5-DFUR	TYMS	TYMS	12509.143	uM	228.63720	1000.00000	-0.2404	-0.6424	0.5600	0.2642	0.9697	1.3392
184B5	NM	Basal	LBH589	HDAC	HDAC	12566.167	uM	0.13317	0.57457	-0.4488	-0.6154	0.5488	0.5171	0.9826	1.5941
184B5	NM	Basal	Lapatinib	EGFR/HER2	ErbB	5896.098	uM	19.73470	1.01420	0.5024	0.4466	0.7535	0.1314	0.9743	1.6038
184A1	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5895.095	uM	0.40767	0.41810	-0.0165	-0.0219	1.6956	0.7104	0.9924	1.4629
184B5	NM	Basal	L-779450	BRAF	MAPK	12566.166	uM	3.60120	8.28470	-0.5360	-0.8326	1.1766	0.2021	0.9933	1.2010
184B5	NM	Basal	JNK-IN-5A	JNK	JNK	12566.168	uM	197.47390	224.21850	0.4789	-0.4434	4.9982	0.0157	0.9558	1.4366
184A1	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5894.095	uM	53.72510	62.72890	-0.1792	-0.0920	1.0901	0.3508	0.940	1.7133
184A1	NM	Basal	Glycyl-H-1152	ROCK2		12509.169	uM	inf	inf	0.8820	0.8820	0.0000	0.0673	0.0092	1.5064
184B5	NM	Basal	Ixabepilone	TUBB	TUBB	5897.095	uM	0.20628	0.87310	-0.9665	-1.0000	0.7614	0.6402	0.9623	1.2197
184B5	NM	Basal	Ixabepilone	TUBB	TUBB	5896.095	uM	0.08255	0.56666	-0.9288	-1.0000	0.5703	0.7131	0.9537	1.5532
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184B5	NM	Basal	Ispinesib	KSP	Kinesin	5897.067	uM	1.94680	2.77930	-0.9633	-0.9674	3.0241	0.4080	0.9827	1.1908
184B5	NM	Basal	Ispinesib	KSP	Kinesin	5896.067	uM	0.56462	3.31620	-0.9349	-1.0000	0.6205	0.4400	0.9084	1.4536

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)