Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
10644.135
uM
1.72590
2.57450
 -0.9306 -0.8286 2.4439 0.5153
0.9521
 0.5273
MX1
Unknown
Unknown
 Nelfinavir
12667.174
uM
6.93420
10.10980
 -0.9543 -1.0000 2.9138 0.1831
0.990
 0.8129
MX1
Unknown
Unknown
 Nilotinib
ABL
nRTK
10644.145
uM
3.15010
3.71960
 -0.5688 -0.4876 4.0955 0.4971
0.9711
 0.4300
MX1
Unknown
Unknown
 NSC 663284
CDC25
CDC
12220.159
uM
0.150
0.25801
 -0.9998 -1.0000 2.0255 1.0392
0.9923
 0.4788
HBL-100
Unknown
Unknown
 17-AAG
HSP90
HSP90
7807.04
uM
1.67060
4.14870
 -0.7759 -0.7682 1.0232 0.4211
0.9891
 2.1435
HBL-100
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7429.074
uM
0.21399
0.25848
 -0.7951 -0.7656 4.9167 0.8819
0.9981
 2.3375
HBL-100
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
7807.016
uM
11.62140
15.50560
 -0.8212 -0.8219 3.3715 0.3669
0.9974
 2.1516
HBL-100
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
7808.016
uM
inf
13.19490
 0.5274 0.7135 4.9687 0.0363
0.6432
 2.2401
HBL-100
Unknown
Unknown
 17-AAG
HSP90
HSP90
7808.05
uM
0.95232
1.51340
 -0.4445 -0.4552 1.3976 0.4994
0.9942
 2.5177
HBL-100
Unknown
Unknown
 5-FU
TYMS
TYMS
7808.017
uM
153.52750
267.86840
 -0.0890 -0.1730 0.5339 0.3993
0.9832
 2.4168
HBL-100
Unknown
Unknown
 AG1024
IGF1R
RTK
7429.066
uM
inf
inf
 0.9919 0.9919 0.0000 0.0080
0.0137
 2.3904
HBL-100
Unknown
Unknown
 AG1478
EGFR
ErbB
7808.016
uM
inf
inf
 0.9515 0.9515 0.0000 -0.0168
0.0597
 2.2401
HBL-100
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
7808.011
uM
91.64120
178.22410
 -0.9131 -0.9831 1.6346 0.3085
0.9967
 2.4301
HBL-100
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
7807.011
uM
80.29730
142.76360
 -0.7730 -0.8163 1.6820 0.3238
0.9983
 2.1620
HBL-100
Unknown
Unknown
 Cetuximab
EGFR
ErbB
7807.042
uM
inf
inf
 1.0098 1.0098 0.0000 -0.0392
-7.7987
 2.0250
HBL-100
Unknown
Unknown
 Cetuximab
EGFR
ErbB
7808.052
uM
inf
inf
 0.9944 0.9944 0.0000 -0.0231
-0.8225
 2.4842
HBL-100
Unknown
Unknown
 CGC-11047
Polyamine analogue
7808.052
uM
inf
0.72086
 0.5882 0.6283 0.8496 0.1837
0.9560
 2.4842
HBL-100
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
7807.017
uM
inf
inf
 -0.4695 -0.4695 0.0000 0.2218
0.4545
 2.2007
HBL-100
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
9226.021
uM
8.73650
13.53040
 -0.6894 -0.7018 2.0049 0.3883
0.9995
 2.5142
HBL-100
Unknown
Unknown
 CPT-11
TOP1
TOP
7808.043
uM
3.95580
3.81630
 -0.1647 0.0821 5.0000 0.2428
0.8707
 2.3907
HBL-100
Unknown
Unknown
 Doxorubicin
TOP2
TOP
7808.043
uM
0.03423
0.04488
 -0.2801 -0.5530 2.7489 0.9385
0.9153
 2.3907
HBL-100
Unknown
Unknown
 Doxorubicin
TOP2
TOP
9226.034
uM
0.06059
0.09525
 -0.8190 -0.7193 1.9706 0.9033
0.9973
 2.6175
HBL-100
Unknown
Unknown
 Epirubicin
TOP2
TOP
7807.017
uM
0.15688
0.25538
 -0.9194 -0.8296 2.0074 0.9144
0.9978
 2.2007
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10644.136
uM
80.20970
150.0160
 0.3780 -0.7441 1.4559 0.0899
0.6828
 0.5562
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10874.152
uM
inf
inf
 0.6467 0.6467 0.0000 0.1312
0.3463
 0.7706