Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7878.016 | uM | inf | 15.01940 | 0.7927 | 0.8386 | 4.9792 | 0.0160 | 0.7114 | 1.4153 | ||
| HCC70 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7856.016 | uM | inf | 11.83740 | 0.7410 | 0.6982 | 0.6309 | 0.0644 | 0.8127 | 0.9156 | ||
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7812.016 | uM | inf | inf | 0.8355 | 0.8355 | 0.0000 | 0.0454 | 0.3718 | 1.0628 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7797.016 | uM | 0.25036 | 0.02995 | 0.2168 | 0.2584 | 0.3426 | 0.4729 | 0.9352 | 0.5155 | ||
| 184A1 | NM | Basal | (Z)-4-Hydroxytamoxifen | ESR1 | 9047.132 | uM | inf | inf | 0.4055 | 0.4055 | 0.0000 | 0.2074 | 0.3073 | 0.6985 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7862.016 | uM | inf | 3.5820 | 0.6087 | 0.7072 | 5.0000 | 0.0671 | 0.8712 | 1.3229 | ||
| MB 157 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 9039.016 | uM | 56.67380 | 1000.00000 | 0.2424 | -0.8928 | 0.3569 | 0.1994 | 0.6376 | 0.5468 | ||
| SUM149PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7917.016 | uM | 274.97130 | 946.23690 | 0.6414 | -1.0000 | 0.8890 | 0.0413 | 0.9052 | 2.9532 | ||
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7809.016 | uM | inf | inf | 0.3854 | 0.3854 | 0.0000 | 0.1556 | 0.5101 | 1.6622 | ||
| SUM159PT | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7918.016 | uM | 75.36610 | 111.09270 | -0.5212 | -1.0000 | 2.8314 | 0.1653 | 0.9046 | 3.1190 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9033.016 | uM | 1140.74090 | 1000.00000 | 0.5737 | 0.0166 | 0.2569 | 0.1413 | 0.8294 | 1.3741 | ||
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12206.157 | uM | 0.76755 | 1.04930 | -0.3319 | -0.3141 | 1.5590 | 0.5114 | 0.9889 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10519.139 | uM | 1.26790 | 1.37170 | -0.0861 | -0.0865 | 2.0272 | 0.4160 | 0.9889 | 1.0177 | |
| SK-BR-3 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 11851.157 | uM | 1.89760 | 1.88790 | -0.0293 | 0.0127 | 5.0000 | 0.3580 | 0.9733 | 1.4707 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10998.151 | uM | 0.59196 | 0.63270 | 0.0499 | -0.0948 | 2.6094 | 0.4574 | 0.9332 | 0.6986 | |
| 184B5 | NM | Basal | XRP44X | ELK3 | MAPK | 12566.171 | uM | 0.34734 | 0.19490 | 0.1674 | 0.1823 | 0.7846 | 0.4183 | 0.9903 | 1.5151 | |
| SUM1315MO2 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12428.157 | uM | 1.02840 | 0.98339 | 0.2789 | 0.1002 | 5.0000 | 0.3657 | 0.8404 | 0.9842 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 10874.151 | uM | 0.39810 | 0.48080 | -0.8735 | -0.7817 | 4.9873 | 0.7696 | 0.9958 | 0.7476 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12220.157 | uM | 0.78424 | 0.95931 | -0.8685 | -0.8693 | 5.0000 | 0.7073 | 0.9972 | 0.3325 | |
| MX1 | Unknown | Unknown | XRP44X | ELK3 | MAPK | 10644.139 | uM | 0.59123 | 1.02640 | -0.9667 | -0.9881 | 1.9773 | 0.8155 | 0.9858 | 0.6077 | |
| HCC1937 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 11849.157 | uM | inf | 4.07330 | 0.6796 | 0.7115 | 4.9999 | 0.1061 | 0.6462 | 1.4559 | |
| Hs 578T | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10694.151 | uM | 1.04140 | 0.97346 | 0.1224 | 0.1396 | 4.8491 | 0.3319 | 0.9971 | 2.4341 | |
| HCC38 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11850.157 | uM | 1.56040 | 1.50450 | 0.0343 | 0.0323 | 1.8299 | 0.3682 | 0.9769 | 2.0943 | |
| HCC1143 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 12112.157 | uM | 11.75790 | 0.56131 | 0.5118 | 0.4877 | 1.2188 | 0.2507 | 0.7951 | 2.0505 | |
| HCC38 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10578.139 | uM | 2.01990 | 2.47790 | -0.2396 | -0.2200 | 1.7843 | 0.3676 | 0.9952 | 1.6434 |