Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5901.084 | uM | 0.08674 | 0.20069 | -0.9407 | -0.9232 | 1.2470 | 0.7548 | 0.9992 | 1.7402 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7530.074 | uM | 0.05589 | 0.08823 | -0.8823 | -0.8633 | 2.1969 | 1.0962 | 0.9992 | 2.0964 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7444.065 | uM | 1.45170 | 2.67320 | -0.9873 | -0.9919 | 1.7904 | 1.1581 | 0.9992 | 0.7419 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7812.017 | uM | 3.44630 | 6.68930 | -0.9960 | -1.0000 | 1.6565 | 0.5582 | 0.9992 | 1.1362 | |
| MX1 | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 10644.145 | uM | 0.04734 | 0.07256 | -1.0000 | -1.0000 | 2.5730 | 1.0527 | 0.9991 | 0.4300 | |
| HCC1937 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 11849.145 | uM | 0.13365 | 0.16967 | -0.8677 | -0.8553 | 4.1787 | 0.8372 | 0.9991 | 1.5253 | |
| HCC1143 | TNBC | Basal A | IKK16 | IKK | NFKB | 7430.093 | uM | 3.9730 | 4.84760 | -0.8497 | -0.8522 | 5.0000 | 0.3517 | 0.9991 | 1.9432 | |
| MX1 | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 10644.145 | uM | 0.04734 | 0.07256 | -1.0000 | -1.0000 | 2.5730 | 1.0527 | 0.9991 | 0.4300 | |
| HCC70 | TNBC | Basal A | Taxol | TUBB | TUBB | 12714.002 | uM | 0.00853 | 0.01048 | -0.9148 | -0.9050 | 5.0000 | 1.1860 | 0.9991 | 0.4328 | |
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 15396.211 | uM | 0.00334 | 0.01326 | -0.6071 | -0.6008 | 0.5726 | 1.0084 | 0.9991 | 0.9137 | |||
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7483.067 | uM | 7.35150 | 12.33760 | -0.7295 | -0.7449 | 1.7619 | 0.3474 | 0.9991 | 3.2893 | |
| HCC1937 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 11849.145 | uM | 0.13365 | 0.16967 | -0.8677 | -0.8553 | 4.1787 | 0.8372 | 0.9991 | 1.5253 | |
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7512.084 | uM | 0.05608 | 0.07520 | -0.9999 | -0.9952 | 3.7340 | 0.9064 | 0.9991 | 0.7511 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7793.007 | uM | 0.00691 | 0.01211 | -0.7351 | -0.7087 | 1.5714 | 1.2066 | 0.9991 | 1.3832 | |
| HBL-100 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7429.084 | uM | 48.25460 | 66.54960 | -0.7786 | -0.7812 | 2.9272 | 0.3710 | 0.9991 | 2.2510 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9028.075 | uM | 0.00457 | 0.00564 | -0.9576 | -0.9350 | 5.0000 | 1.7932 | 0.9991 | 0.6011 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9648.037 | uM | 0.03015 | 0.0370 | -0.9033 | -0.8903 | 5.0000 | 1.1329 | 0.9991 | 0.6971 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| HCC3153 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10577.14 | uM | 2.4650 | 3.61860 | -0.9817 | -0.9832 | 2.8326 | 0.5933 | 0.9991 | 0.9722 | |
| HCC1937 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7452.084 | uM | 0.36891 | 0.53806 | -0.9076 | -0.8914 | 2.7117 | 0.6139 | 0.9991 | 1.6800 | |
| HCC70 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7857.017 | uM | 1.60450 | 2.36240 | -0.9732 | -0.9789 | 2.8032 | 0.7284 | 0.9991 | 1.1840 | |
| Hs 578T | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 10694.147 | uM | 1.63690 | 3.29360 | -0.6479 | -0.6730 | 1.2196 | 0.3912 | 0.9991 | 2.3818 |