Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 7483.065 | uM | 21.97690 | 39.36970 | -0.5162 | -0.5201 | 1.2230 | 0.5796 | 0.9993 | 3.0487 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 12702.177 | uM | 0.09085 | 0.11182 | -0.9173 | -0.9126 | 5.0000 | 0.8363 | 0.9993 | 1.5730 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5901.074 | uM | 0.01918 | 0.02631 | -0.9339 | -0.9340 | 3.3341 | 1.3219 | 0.9993 | 1.8718 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 10872.145 | uM | 0.13031 | 0.18552 | -0.7385 | -0.7306 | 2.5497 | 0.7881 | 0.9993 | 1.6308 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7436.085 | uM | 0.34731 | 0.57214 | -0.9575 | -0.9591 | 2.1456 | 0.6174 | 0.9993 | 1.2621 | |
| HCC38 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7469.065 | uM | 56.36950 | 98.13920 | -0.6634 | -0.6778 | 1.5453 | 0.6859 | 0.9993 | 2.0006 | |
| SUM149PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14652.189 | uM | 0.50417 | 0.60504 | -0.7406 | -0.7440 | 4.9981 | 0.6337 | 0.9993 | 2.3317 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7443.065 | uM | 35.62970 | 56.68970 | -0.9861 | -0.9845 | 2.3432 | 0.8811 | 0.9992 | 0.8818 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7432.084 | uM | 0.01028 | 0.01685 | -0.9998 | -0.9951 | 2.2156 | 1.1594 | 0.9992 | 0.8538 | |
| AU565 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10880.152 | uM | 1.58810 | 2.95150 | -0.9114 | -0.9095 | 1.6722 | 0.5940 | 0.9992 | 1.5019 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7444.084 | uM | 0.02965 | 0.04679 | -0.9954 | -0.9959 | 2.4028 | 1.0317 | 0.9992 | 0.8647 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5901.084 | uM | 0.08674 | 0.20069 | -0.9407 | -0.9232 | 1.2470 | 0.7548 | 0.9992 | 1.7402 | |
| CAMA-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5912.091 | uM | 21.42560 | 28.67010 | -0.9748 | -0.9689 | 3.6999 | 0.4290 | 0.9992 | 1.0917 | |
| HCC70 | TNBC | Basal A | Taxol | TUBB | TUBB | 9501.002 | uM | 0.00722 | 0.01212 | -0.6813 | -0.6365 | 1.5836 | 1.0061 | 0.9992 | 1.0082 | |
| HCC2185 | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7849.011 | uM | 4.30770 | 11.64210 | -0.9997 | -1.0000 | 1.1050 | 0.6329 | 0.9992 | 0.5467 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7812.017 | uM | 3.44630 | 6.68930 | -0.9960 | -1.0000 | 1.6565 | 0.5582 | 0.9992 | 1.1362 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| HCC1806 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12239.165 | uM | 9.67380 | 17.26610 | -0.8465 | -0.9909 | 1.8858 | 0.2211 | 0.9992 | 2.0705 | |
| SUM159PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7919.04 | uM | 0.00594 | 0.00689 | -0.2375 | -0.2460 | 2.7121 | 0.9268 | 0.9992 | 3.7375 | |
| SUM149PT | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7530.067 | uM | 12.6640 | 14.92770 | -0.2602 | -0.2629 | 2.5691 | 0.2388 | 0.9992 | 2.0748 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7469.074 | uM | 0.06193 | 0.09293 | -0.9586 | -0.9333 | 2.5945 | 1.1124 | 0.9992 | 1.9843 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7469.074 | uM | 0.06193 | 0.09293 | -0.9586 | -0.9333 | 2.5945 | 1.1124 | 0.9992 | 1.9843 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7444.065 | uM | 1.45170 | 2.67320 | -0.9873 | -0.9919 | 1.7904 | 1.1581 | 0.9992 | 0.7419 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 7485.086 | uM | 0.02196 | 0.04236 | -0.2162 | -0.2393 | 0.5951 | 0.6420 | 0.9992 | 3.3609 |