Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 9233.12 | uM | 0.01453 | 0.01483 | -0.1546 | -0.0524 | 5.0000 | 0.6951 | 0.9750 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7809.018 | uM | 0.02987 | 0.02334 | 0.2866 | 0.3546 | 5.0000 | 0.3657 | 0.9630 | 1.6742 | |
| 600MPE | HR+ | Luminal | Bosutinib | Src | nRTK | 12224.145 | uM | 6.17790 | 4.29030 | 0.3962 | 0.4192 | 5.0000 | 0.1266 | 0.9757 | 0.9737 | |
| BT-483 | HR+ | Luminal | Bosutinib | Src | nRTK | 11855.145 | uM | 3.66260 | 4.19030 | -0.8184 | -0.4801 | 5.0000 | 0.5661 | 0.6911 | 0.5070 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5904.067 | uM | 12.39380 | 15.43930 | -0.9979 | -1.0000 | 5.0000 | 0.3909 | 0.9919 | 1.0398 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 7808.052 | uM | 0.01036 | 0.01169 | -0.8053 | -0.4166 | 5.0000 | 0.9087 | 0.9473 | 2.4842 | |
| BT-549 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14122.189 | uM | 0.14922 | 0.16636 | -0.8306 | -0.3612 | 5.0000 | 0.6812 | 0.6090 | 3.0232 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10518.138 | uM | 0.23611 | 0.23002 | 0.0120 | 0.0612 | 5.0000 | 0.4780 | 0.9213 | 1.3413 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 5895.098 | uM | 1.84620 | 1.07940 | 0.2337 | 0.4659 | 5.0000 | 0.0845 | 0.8011 | 1.4041 | |
| HCC1428 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11936.157 | uM | 1.30930 | 1.17550 | 0.2690 | 0.2084 | 5.0000 | 0.3632 | 0.8620 | 0.9133 | |
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9158.049 | uM | 0.00737 | 0.00871 | -0.8389 | -0.6523 | 5.0000 | 1.1719 | 0.9370 | 0.4082 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| HCC1143 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7430.085 | uM | 0.03311 | 0.02148 | 0.4350 | 0.4426 | 5.0000 | 0.4097 | 0.9884 | 1.9592 | |
| BT-549 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14152.189 | uM | 0.13221 | 0.14889 | -0.7820 | -0.4057 | 5.0000 | 0.7398 | 0.6095 | 2.1948 | |
| 184B5 | NM | Basal | 2-deoxyglucose | 12979.177 | uM | 559.39550 | 583.2410 | -0.1158 | -0.1161 | 5.0000 | 0.2148 | 0.7107 | 0.5647 | |||
| 21NT | HER2amp | - | Mebendazole | 13575.174 | uM | 0.70544 | 0.60467 | 0.2760 | 0.2687 | 5.0000 | 0.2944 | 0.9408 | 1.5845 | |||
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9254.002 | uM | 0.00740 | 0.00860 | -0.5219 | -0.5591 | 5.0000 | 0.8610 | 0.9829 | 0.3983 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9163.03 | uM | 26.3970 | 32.88280 | -0.9993 | -0.9998 | 5.0000 | 0.3249 | 0.9959 | 0.3535 | |
| HCC1143 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7810.011 | uM | 133.08090 | 163.51440 | -0.8974 | -0.9001 | 5.0000 | 0.3161 | 0.9965 | 0.9243 | |
| BT-483 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9186.026 | uM | 9.98070 | 8.38730 | 0.7741 | 0.2905 | 5.0000 | -0.0274 | 0.7463 | 0.5108 | |
| 600MPE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13091.174 | uM | 0.14887 | 0.16877 | -0.5761 | -0.4361 | 5.0000 | 0.6871 | 0.9453 | 0.7967 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 7848.001 | uM | 0.06638 | 0.07453 | -0.5258 | -0.3922 | 5.0000 | 0.6420 | 0.9828 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 7849.001 | uM | 0.07833 | 0.08466 | -0.4193 | -0.2372 | 5.0000 | 0.5266 | 0.9775 | 0.5308 |