Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
184B5
NM
Basal
 Bortezomib
Proteasome
Proteasome
5896.074
uM
0.01517
0.03188
 -0.7992 -0.7384 1.2208 1.1454
0.9925
 1.4124
SUM52PE
HR+
Luminal
 (Z)-4-Hydroxytamoxifen
ESR1
7923.016
uM
inf
inf
 -0.2746 -0.2746 0.0000 1.1451
0.5151
 0.6280
MDA-MB-157
TNBC
Basal B
 GSK923295
CENPE
Kinesin
10093.001
uM
0.00660
0.01553
 -0.9516 -0.8558 1.1659 1.1448
0.9216
 0.5759
BT-474
HER2amp
Luminal
 Afatinib
EGFR/HER2
ErbB
12178.158
uM
0.00866
0.02277
 -0.9958 -0.8611 1.0356 1.1447
0.9876
 0.7379
MDA-MB-157
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7496.074
uM
0.05608
0.11046
 -0.9513 -0.9648 1.5858 1.1437
0.9961
 1.3504
MDA-MB-157
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
7496.074
uM
0.05608
0.11046
 -0.9513 -0.9648 1.5858 1.1437
0.9961
 1.3504
HCC38
TNBC
Basal B
 Doxorubicin
TOP2
TOP
10268.007
uM
0.00960
0.02970
 -0.8620 -0.8465 0.8773 1.1436
0.9774
 1.3306
HCC1806
TNBC
Basal A
 Gemcitabine
DNA replication
DNA replication
9376.011
uM
0.0020
0.00271
 -0.4566 -0.3593 1.7705 1.1418
0.9864
 1.5809
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
14825.203
uM
0.00933
0.01354
 -0.8853 -0.7370 2.4340 1.1414
0.9756
 0.5604
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
14825.203
uM
0.00933
0.01354
 -0.8853 -0.7370 2.4340 1.1414
0.9756
 0.5604
MDA-MB-134-VI
HR+
Luminal
 17-AAG
HSP90
HSP90
7877.05
uM
0.03175
0.04491
 -0.9920 -0.9506 3.0706 1.1407
0.9988
 0.5502
MDA-MB-415
HR+
Luminal
 17-AAG
HSP90
HSP90
7897.037
uM
0.01547
0.02922
 -0.9359 -0.7663 1.4609 1.1406
0.9681
 0.7255
BT-20
TNBC
Basal A
 Trichostatin A
HDAC
HDAC
10385.065
uM
0.36381
5.4850
 -0.9923 -1.0000 0.4049 1.1403
0.6735
 0.6599
MDA-MB-468
TNBC
Basal A
 GSK461364
PLK1
PLK
7905.001
uM
0.00337
0.00440
 -0.8845 -0.6726 3.1893 1.1402
0.9093
 0.7433
HCC202
HER2amp
Luminal
 Ispinesib
KSP
Kinesin
7458.067
uM
0.00782
0.01292
 -0.9999 -0.8837 2.0273 1.1391
0.9926
 0.5714
HCC1187
TNBC
Basal A
 Taxol
TUBB
TUBB
7812.002
uM
0.00801
0.00970
 -0.8107 -0.8039 5.0000 1.1382
0.9988
 1.0730
HCC1954
HER2amp
Basal A
 Omipalisib
PI3K
PI3K
7454.087
uM
0.00381
0.01412
 -0.8082 -0.8406 0.7530 1.1374
0.9564
 1.2157
JIMT-1
HER2amp
Basal
 Bortezomib
Proteasome
Proteasome
14743.203
uM
0.01175
0.01847
 -0.7785 -0.7705 2.0610 1.1373
0.9983
 2.1139
JIMT-1
HER2amp
Basal
 Bortezomib
Proteasome
Proteasome
14743.203
uM
0.01175
0.01847
 -0.7785 -0.7705 2.0610 1.1373
0.9983
 2.1139
HCC1187
TNBC
Basal A
 Trichostatin A
HDAC
HDAC
7432.065
uM
1.82480
2.79630
 -0.9944 -0.9900 2.5582 1.1358
0.9990
 0.7981
HCC1428
HR+
Luminal
 Trichostatin A
HDAC
HDAC
7443.065
uM
1.70780
2.75150
 -0.9769 -0.9745 2.2675 1.1356
0.9991
 0.8818
UACC-812
HER2amp
Luminal
 Geldanamycin
HSP90
HSP90
10150.012
uM
0.02042
0.02445
 -0.7512 -0.7308 4.9997 1.1335
0.9985
 0.4611
MDA-MB-361
HER2amp
Luminal
 17-AAG
HSP90
HSP90
9648.037
uM
0.03015
0.0370
 -0.9033 -0.8903 5.0000 1.1329
0.9991
 0.6971
MDA-MB-175-VII
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14759.203
uM
0.01669
0.02621
 -0.8345 -0.8419 2.1869 1.1312
0.9990
 1.7099
MDA-MB-175-VII
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14759.203
uM
0.01669
0.02621
 -0.8345 -0.8419 2.1869 1.1312
0.9990
 1.7099