Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Geldanamycin | HSP90 | HSP90 | 7807.04 | uM | 0.03553 | 0.04820 | -0.3708 | -0.2711 | 1.4204 | 0.7397 | 0.9883 | 2.1435 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 7808.001 | uM | 0.19841 | 1.24310 | -0.9041 | -1.0000 | 0.5987 | 0.5723 | 0.9550 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 9226.001 | uM | 0.70349 | 3.20790 | -0.7877 | -1.0000 | 0.7241 | 0.4535 | 0.9635 | 2.6569 | |
| HBL-100 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 7808.001 | uM | 0.00198 | 0.00195 | -0.7793 | 0.0376 | 4.9991 | 0.6852 | 0.5924 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 9226.001 | uM | 0.11473 | 5.26970 | -0.7351 | -1.0000 | 0.2871 | 0.4874 | 0.6569 | 2.6569 | |
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7808.016 | uM | inf | 13.19490 | 0.5274 | 0.7135 | 4.9687 | 0.0363 | 0.6432 | 2.2401 | ||
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7807.016 | uM | 11.62140 | 15.50560 | -0.8212 | -0.8219 | 3.3715 | 0.3669 | 0.9974 | 2.1516 | ||
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7808.05 | uM | 0.95232 | 1.51340 | -0.4445 | -0.4552 | 1.3976 | 0.4994 | 0.9942 | 2.5177 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7808.017 | uM | 153.52750 | 267.86840 | -0.0890 | -0.1730 | 0.5339 | 0.3993 | 0.9832 | 2.4168 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7808.016 | uM | inf | inf | 0.9515 | 0.9515 | 0.0000 | -0.0168 | 0.0597 | 2.2401 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7807.016 | uM | inf | inf | 0.9359 | 0.9359 | 0.0000 | 0.0541 | 0.4439 | 2.1516 | |
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7808.011 | uM | 91.64120 | 178.22410 | -0.9131 | -0.9831 | 1.6346 | 0.3085 | 0.9967 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7429.102 | uM | inf | 0.00269 | 0.9697 | 0.9727 | 4.9973 | 0.0039 | 0.6691 | 2.4347 | |
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 7808.052 | uM | inf | 0.72086 | 0.5882 | 0.6283 | 0.8496 | 0.1837 | 0.9560 | 2.4842 | ||
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7807.017 | uM | inf | inf | -0.4695 | -0.4695 | 0.0000 | 0.2218 | 0.4545 | 2.2007 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 7808.043 | uM | 3.95580 | 3.81630 | -0.1647 | 0.0821 | 5.0000 | 0.2428 | 0.8707 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 9226.034 | uM | 2.78310 | 4.5530 | -0.6561 | -0.6763 | 1.7380 | 0.3659 | 0.9993 | 2.6175 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 9226.002 | uM | 0.00159 | 0.00118 | 0.3255 | 0.2348 | 2.1218 | 0.5458 | 0.9405 | 2.4245 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7808.002 | uM | 0.00194 | 0.00155 | 0.3152 | 0.1983 | 2.2864 | 0.5513 | 0.9438 | 2.3302 | |
| HBL-100 | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7429.09 | uM | inf | 76.97320 | 0.9353 | 0.8278 | 3.5846 | -0.0027 | 0.7593 | 2.2456 | |
| HBL-100 | Unknown | Unknown | Etoposide | TOP2 | TOP | 7429.074 | uM | 2.71640 | 5.26150 | -0.7559 | -0.7655 | 1.4047 | 0.5711 | 0.9988 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 7429.084 | uM | inf | 0.12857 | 0.6858 | 0.7716 | 5.0000 | 0.1377 | 0.8694 | 2.2510 | |
| HBL-100 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 7429.067 | uM | 0.02923 | 0.03665 | -0.8592 | -0.4894 | 3.0166 | 0.7627 | 0.9592 | 2.2169 |