Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 NSC 663284
CDC25
CDC
12220.159
uM
0.150
0.25801
 -0.9998 -1.0000 2.0255 1.0392
0.9923
 0.4788
MX1
Unknown
Unknown
 NSC 663284
CDC25
CDC
10644.14
uM
0.66207
0.82476
 -1.0000 -1.0000 5.0000 0.8690
0.9955
 0.4302
MX1
Unknown
Unknown
 NU6102
CDK1/2
CDK
10644.147
uM
2.23610
5.50710
 -1.0000 -1.0000 1.2189 0.4234
0.9711
 0.4349
MX1
Unknown
Unknown
 NU6102
CDK1/2
CDK
10874.147
uM
8.77790
15.5340
 -0.9506 -1.0000 1.9247 0.2286
0.9925
 0.7482
HBL-100
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
7808.016
uM
inf
13.19490
 0.5274 0.7135 4.9687 0.0363
0.6432
 2.2401
HBL-100
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
7807.016
uM
11.62140
15.50560
 -0.8212 -0.8219 3.3715 0.3669
0.9974
 2.1516
HBL-100
Unknown
Unknown
 17-AAG
HSP90
HSP90
7808.05
uM
0.95232
1.51340
 -0.4445 -0.4552 1.3976 0.4994
0.9942
 2.5177
HBL-100
Unknown
Unknown
 5-FU
TYMS
TYMS
7808.017
uM
153.52750
267.86840
 -0.0890 -0.1730 0.5339 0.3993
0.9832
 2.4168
HBL-100
Unknown
Unknown
 AG1478
EGFR
ErbB
7808.016
uM
inf
inf
 0.9515 0.9515 0.0000 -0.0168
0.0597
 2.2401
HBL-100
Unknown
Unknown
 AG1478
EGFR
ErbB
7807.016
uM
inf
inf
 0.9359 0.9359 0.0000 0.0541
0.4439
 2.1516
HBL-100
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7429.074
uM
0.21399
0.25848
 -0.7951 -0.7656 4.9167 0.8819
0.9981
 2.3375
HBL-100
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
7808.011
uM
91.64120
178.22410
 -0.9131 -0.9831 1.6346 0.3085
0.9967
 2.4301
HBL-100
Unknown
Unknown
 Cetuximab
EGFR
ErbB
7808.052
uM
inf
inf
 0.9944 0.9944 0.0000 -0.0231
-0.8225
 2.4842
HBL-100
Unknown
Unknown
 Cetuximab
EGFR
ErbB
7429.102
uM
inf
0.00269
 0.9697 0.9727 4.9973 0.0039
0.6691
 2.4347
HBL-100
Unknown
Unknown
 CGC-11047
Polyamine analogue
7808.052
uM
inf
0.72086
 0.5882 0.6283 0.8496 0.1837
0.9560
 2.4842
HBL-100
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
7807.017
uM
inf
inf
 -0.4695 -0.4695 0.0000 0.2218
0.4545
 2.2007
HBL-100
Unknown
Unknown
 CPT-11
TOP1
TOP
7808.043
uM
3.95580
3.81630
 -0.1647 0.0821 5.0000 0.2428
0.8707
 2.3907
HBL-100
Unknown
Unknown
 CPT-11
TOP1
TOP
9226.034
uM
2.78310
4.5530
 -0.6561 -0.6763 1.7380 0.3659
0.9993
 2.6175
HBL-100
Unknown
Unknown
 Docetaxel
TUBB
TUBB
9226.002
uM
0.00159
0.00118
 0.3255 0.2348 2.1218 0.5458
0.9405
 2.4245
HBL-100
Unknown
Unknown
 Docetaxel
TUBB
TUBB
7808.002
uM
0.00194
0.00155
 0.3152 0.1983 2.2864 0.5513
0.9438
 2.3302
HBL-100
Unknown
Unknown
 Erlotinib
EGFR
ErbB
7429.09
uM
inf
76.97320
 0.9353 0.8278 3.5846 -0.0027
0.7593
 2.2456
HBL-100
Unknown
Unknown
 Etoposide
TOP2
TOP
7429.074
uM
2.71640
5.26150
 -0.7559 -0.7655 1.4047 0.5711
0.9988
 2.3375
HBL-100
Unknown
Unknown
 Gefitinib
EGFR
ErbB
7807.016
uM
16.03490
32.79390
 -0.0134 -1.0000 1.5355 0.1363
0.9633
 2.1516
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10644.136
uM
80.20970
150.0160
 0.3780 -0.7441 1.4559 0.0899
0.6828
 0.5562
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10874.152
uM
inf
inf
 0.6467 0.6467 0.0000 0.1312
0.3463
 0.7706