Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9033.075 | uM | 5.06140 | 23.680 | -0.7541 | -0.9393 | 0.6852 | 0.5177 | 0.9975 | 0.9560 | |
| T47D | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 10939.147 | uM | 0.93744 | 2.01970 | -0.8498 | -0.9007 | 1.3421 | 0.5325 | 0.9976 | 1.7195 | |
| T47D | HR+ | Luminal | PD 98059 | MEK | MAPK | 10939.152 | uM | inf | inf | 0.8987 | 0.8987 | 0.0000 | 0.0503 | -0.1161 | 1.6952 | |
| T47D | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 7542.1 | uM | 13.61710 | 17.05810 | -0.9457 | -0.9488 | 4.7221 | 0.1775 | 0.9978 | 1.3201 | |
| T47D | HR+ | Luminal | PD184352 | MEK | MAPK | 10939.155 | uM | inf | inf | 0.9513 | 0.9513 | 0.0000 | 0.0411 | 0.0000 | 1.5150 | |
| T47D | HR+ | Luminal | PD184352 | MEK | MAPK | 10939.155 | uM | inf | inf | 0.9513 | 0.9513 | 0.0000 | 0.0411 | 0.0000 | 1.5150 | |
| T47D | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7542.095 | uM | inf | inf | 0.8872 | 0.8872 | 0.0000 | 0.0577 | 0.350 | 1.2904 | |
| T47D | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7543.095 | uM | inf | 0.73151 | 0.9263 | 0.9038 | 5.0000 | 0.0510 | 0.7245 | 1.1854 | |
| T47D | HR+ | Luminal | PS-1145 | IKK | NFKB | 7543.065 | uM | inf | inf | 0.8542 | 0.8542 | 0.0000 | 0.0523 | 0.0493 | 1.2714 | |
| T47D | HR+ | Luminal | PS-1145 | IKK | NFKB | 7542.065 | uM | inf | 564.02340 | 0.8917 | 0.8826 | 2.0443 | 0.0042 | 0.8478 | 1.2381 | |
| T47D | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7543.067 | uM | inf | 46.99550 | 0.6867 | 0.6861 | 4.8857 | 0.0055 | 0.8955 | 1.2437 | |
| T47D | HR+ | Luminal | Ribavirin | 15340.211 | uM | inf | 11.53030 | 0.6704 | 0.6701 | 4.9483 | 0.0040 | 0.9110 | 1.5685 | |||
| T47D | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10939.144 | uM | 269.49980 | 995.58560 | 0.6947 | -0.7215 | 0.6836 | 0.0745 | 0.6340 | 1.7115 | |
| T47D | HR+ | Luminal | Selumetinib | MEK | MAPK | 10939.155 | uM | inf | inf | 0.9555 | 0.9555 | 0.0000 | 0.0318 | -0.020 | 1.5150 | |
| T47D | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10939.153 | uM | 1.86790 | 2.39280 | -0.1244 | -0.1483 | 1.0486 | 0.3175 | 0.9928 | 1.7112 | |
| T47D | HR+ | Luminal | Sirolimus | MTOR | MTOR | 9033.068 | uM | 0.29341 | 9.30280 | -0.7901 | -1.0000 | 0.3178 | 0.5971 | 0.8637 | 0.9662 | |
| T47D | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7543.069 | uM | 0.47443 | 4.78060 | 0.1173 | -0.3414 | 0.2253 | 0.3912 | 0.9455 | 1.4340 | |
| T47D | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7543.084 | uM | 16.17730 | 13.02060 | 0.2936 | 0.3311 | 5.0000 | 0.2200 | 0.9493 | 1.3431 | |
| T47D | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7543.067 | uM | 9.90130 | 12.33280 | -0.9958 | -0.9991 | 5.0000 | 0.3588 | 0.9981 | 1.2437 | |
| T47D | HR+ | Luminal | Taxol | TUBB | TUBB | 12720.002 | uM | 0.00991 | 0.00999 | -0.1069 | -0.0209 | 5.0000 | 0.6437 | 0.9829 | 1.0368 | |
| T47D | HR+ | Luminal | Taxol | TUBB | TUBB | 9897.002 | uM | 0.00762 | 0.00898 | -0.6614 | -0.6336 | 5.0000 | 1.0525 | 0.9987 | 0.4068 | |
| T47D | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10939.152 | uM | 1.27660 | 1.26120 | 0.0133 | 0.0294 | 5.0000 | 0.2556 | 0.9918 | 1.6952 | |
| T47D | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10939.148 | uM | inf | 19.54280 | 0.7498 | 0.7216 | 1.7774 | 0.0429 | 0.8178 | 1.6568 | |
| T47D | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10939.144 | uM | 2.02380 | 20.63120 | -0.8123 | -1.0000 | 0.4732 | 0.4463 | 0.8296 | 1.7115 | |
| T47D | HR+ | Luminal | Torkinib | 15340.211 | uM | 0.00038 | 0.00069 | -0.2049 | -0.1299 | 0.3943 | 0.8877 | 0.9641 | 1.5685 |