Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | IKK16 | IKK | NFKB | 7547.093 | uM | 3.70140 | 4.74720 | -0.9590 | -0.9608 | 4.3084 | 0.5236 | 0.9326 | 1.1087 | |
| UACC-812 | HER2amp | Luminal | IKK16 | IKK | NFKB | 10580.1 | uM | 5.03630 | 6.27380 | -0.9915 | -1.0000 | 5.0000 | 0.4828 | 0.9665 | 0.7968 | |
| UACC-812 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7547.092 | uM | 8.38850 | 21.76390 | -0.9843 | -1.0000 | 1.1523 | 0.6563 | 0.9004 | 0.9866 | |
| UACC-812 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7547.095 | uM | 0.02634 | 2.43190 | -0.9827 | -1.0000 | 0.2428 | 0.6272 | 0.5941 | 1.0102 | |
| UACC-812 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 10420.095 | uM | 0.00405 | 0.00426 | -0.9993 | -0.0422 | 1.5655 | 0.6669 | 0.5965 | 0.5783 | |
| UACC-812 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10580.144 | uM | 1.4810 | 1.37530 | 0.1114 | 0.1054 | 3.1967 | 0.3905 | 0.8911 | 0.8541 | |
| UACC-812 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 11938.144 | uM | 1.49340 | 1.71540 | -0.4340 | -0.5000 | 5.0000 | 0.6048 | 0.8993 | 0.6445 | |
| UACC-812 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10754.144 | uM | 0.64710 | 0.61740 | 0.0735 | 0.1047 | 5.0000 | 0.3853 | 0.9856 | 0.8390 | |
| UACC-812 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 11938.161 | uM | 4.85250 | 36.98340 | -0.2470 | -1.0000 | 0.5409 | 0.3150 | 0.6470 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10580.137 | uM | 14.89640 | 1000.00000 | 0.3329 | -0.7444 | 0.2168 | 0.2357 | 0.7210 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10754.149 | uM | 11.96010 | 5.77630 | 0.3701 | 0.2621 | 1.0205 | 0.1325 | 0.9581 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7547.098 | uM | 0.15188 | 12.38190 | -0.0571 | -1.0000 | 0.2496 | 0.4562 | 0.7457 | 1.0399 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 11938.154 | uM | 0.13458 | 0.25772 | -0.9831 | -0.9884 | 1.6789 | 0.8490 | 0.9590 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 10754.154 | uM | 0.14169 | 0.27092 | -0.7691 | -0.7889 | 1.4609 | 0.6995 | 0.9942 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11938.154 | uM | 0.27751 | 1.07910 | -0.9977 | -1.0000 | 0.8090 | 0.6488 | 0.9325 | 0.6375 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10754.154 | uM | 2.32050 | 5.79750 | -0.9836 | -1.0000 | 1.1998 | 0.3163 | 0.9698 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10580.142 | uM | 2.10970 | 4.16050 | -0.9752 | -1.0000 | 1.6178 | 0.5390 | 0.9889 | 0.8039 | |
| UACC-812 | HER2amp | Luminal | Mebendazole | 13078.174 | uM | 4.07970 | 51.75050 | -0.1950 | -1.0000 | 0.4325 | 0.3427 | 0.5767 | 0.6238 | |||
| UACC-812 | HER2amp | Luminal | Methylglyoxal | 13078.184 | uM | 430.98580 | 1000.00000 | -0.9987 | -0.7092 | 1.0492 | 0.5284 | 0.8894 | 0.6800 | |||
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14227.189 | uM | 0.28507 | 0.31850 | -0.2854 | -0.1142 | 1.8548 | 0.5125 | 0.9520 | 1.2712 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14227.189 | uM | 0.28507 | 0.31850 | -0.2854 | -0.1142 | 1.8548 | 0.5125 | 0.9520 | 1.2712 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 11938.145 | uM | 0.12429 | 0.24022 | -0.9970 | -1.0000 | 1.6673 | 0.9860 | 0.9564 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 11938.145 | uM | 0.12429 | 0.24022 | -0.9970 | -1.0000 | 1.6673 | 0.9860 | 0.9564 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10580.145 | uM | 0.14153 | 0.25065 | -0.7017 | -0.6324 | 1.4303 | 0.7825 | 0.9578 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10580.145 | uM | 0.14153 | 0.25065 | -0.7017 | -0.6324 | 1.4303 | 0.7825 | 0.9578 | 0.9000 |