Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 11852.158 | uM | inf | 2.29610 | 0.6736 | 0.6910 | 4.9998 | 0.0587 | 0.9472 | 1.3172 | |
| SUM52PE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7539.072 | uM | 110.92170 | 385.68060 | 0.3516 | -1.0000 | 0.8816 | 0.1192 | 0.8451 | 1.4799 | |
| SUM52PE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10695.072 | uM | 35.67460 | 38.16910 | -0.2003 | -0.2010 | 4.9998 | 0.1093 | 0.9898 | 1.0788 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14811.203 | uM | 0.00412 | 0.01039 | -0.5052 | -0.4361 | 0.6785 | 0.9522 | 0.9623 | 1.0107 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14811.203 | uM | 0.00412 | 0.01039 | -0.5052 | -0.4361 | 0.6785 | 0.9522 | 0.9623 | 1.0107 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7541.074 | uM | 0.02494 | 0.03177 | -0.5695 | -0.5293 | 2.9811 | 1.0214 | 0.9964 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7541.074 | uM | 0.02494 | 0.03177 | -0.5695 | -0.5293 | 2.9811 | 1.0214 | 0.9964 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Bosutinib | Src | nRTK | 11852.145 | uM | 1.86730 | 1.9460 | 0.0377 | -0.0187 | 0.8889 | 0.3393 | 0.9796 | 1.5550 | |
| SUM52PE | HR+ | Luminal | Bosutinib | Src | nRTK | 10695.145 | uM | 1.05630 | 2.8090 | -0.9219 | -0.9181 | 1.0659 | 0.5468 | 0.9925 | 1.1360 | |
| SUM52PE | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9878.011 | uM | 21.95380 | 60.16540 | -0.8143 | -0.9456 | 1.0531 | 0.4696 | 0.9885 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9889.021 | uM | 19.94970 | 51.32010 | -0.7717 | -0.8551 | 1.0552 | 0.4818 | 0.9953 | 1.4017 | |
| SUM52PE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7923.018 | uM | inf | inf | 0.3861 | 0.3861 | 0.0000 | 0.4157 | -0.1034 | 0.7947 | |
| SUM52PE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9878.006 | uM | inf | inf | 0.8598 | 0.8598 | 0.0000 | 0.0820 | 0.0476 | 1.3968 | |
| SUM52PE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7923.018 | uM | 0.15750 | 6.39610 | -0.9994 | -1.0000 | 0.2966 | 1.0403 | 0.7812 | 0.7947 | ||
| SUM52PE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9878.006 | uM | 5.79490 | 136.31480 | -0.8412 | -1.0000 | 0.3479 | 0.6811 | 0.7935 | 1.3968 | ||
| SUM52PE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9889.034 | uM | 54.0240 | 535.83740 | -0.8034 | -1.0000 | 0.4788 | 0.4696 | 0.8855 | 1.3742 | ||
| SUM52PE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7923.017 | uM | 0.04731 | 0.52972 | -0.9675 | -1.0000 | 0.4548 | 1.0438 | 0.7576 | 0.6267 | |
| SUM52PE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9878.017 | uM | 2.0790 | 6.3460 | -0.9071 | -0.9796 | 0.9722 | 0.5629 | 0.9931 | 1.3463 | |
| SUM52PE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9889.021 | uM | 1.71690 | 5.1070 | -0.8666 | -0.8968 | 0.9425 | 0.5796 | 0.9968 | 1.4017 | |
| SUM52PE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7540.078 | uM | 1.66230 | 4.76430 | -0.9011 | -0.9849 | 1.0338 | 0.4706 | 0.9675 | 0.9523 | |
| SUM52PE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9889.034 | uM | 0.96215 | 1.59940 | -0.6355 | -0.5308 | 1.4235 | 0.4431 | 0.9888 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 11852.155 | uM | 0.21851 | 0.11640 | 0.4129 | 0.2934 | 1.4031 | 0.3499 | 0.5919 | 1.5196 | |
| SUM52PE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10695.146 | uM | inf | 0.33675 | 0.7413 | 0.7803 | 4.9988 | 0.0767 | 0.8089 | 1.4179 | |
| SUM52PE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13570.176 | uM | inf | inf | 0.7219 | 0.7219 | 0.0000 | 0.3099 | 0.0434 | 0.4076 | |
| SUM52PE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12969.176 | uM | inf | inf | 0.8900 | 0.8900 | 0.0000 | 0.0494 | 0.2176 | 1.0709 |