Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7553.074 | 0.9345 | 0.8625 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7553.074 | 0.9876 | 0.9739 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7553.074 | 0.9287 | 0.8503 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7553.074 | 0.9153 | 0.8223 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7553.074 | 0.6965 | 0.3675 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7553.074 | 0.5651 | 0.0979 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7553.074 | 0.4486 | -0.1388 | 0.9515 | |
| ZR-75-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7553.074 | 0.3174 | -0.4013 | 0.9515 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7555.074 | 0.9094 | 0.8893 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7555.074 | 0.9631 | 0.9554 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7555.074 | 0.8695 | 0.8392 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7555.074 | 0.8158 | 0.7702 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7555.074 | 0.6726 | 0.5768 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7555.074 | 0.5616 | 0.4153 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7555.074 | 0.4511 | 0.2411 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7555.074 | 0.3360 | 0.0402 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7555.074 | 0.2768 | -0.0739 | 1.6682 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.000171 | uM | 12509.164 | 0.8385 | 0.7259 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.000853 | uM | 12509.164 | 0.6888 | 0.4639 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.00427 | uM | 12509.164 | 0.7302 | 0.5372 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.0213 | uM | 12509.164 | 0.6638 | 0.4194 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.107 | uM | 12509.164 | 0.6689 | 0.4285 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 0.533 | uM | 12509.164 | 0.6509 | 0.3962 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 2.67 | uM | 12509.164 | 0.6319 | 0.3620 | 1.1949 | |
| 184A1 | NM | Basal | Everolimus | MTOR | MTOR | 13.3 | uM | 12509.164 | 0.4491 | 0.0234 | 1.1949 |