Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7499.074 | 1.0216 | 1.0598 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7499.074 | 1.0322 | 1.0894 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7499.074 | 0.9181 | 0.7774 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7499.074 | 0.8943 | 0.7140 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7499.074 | 0.8181 | 0.5155 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7499.074 | 0.7273 | 0.2881 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7500.074 | 0.8217 | 0.3788 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7500.074 | 1.1864 | 1.7648 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7500.074 | 0.9966 | 0.9872 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7500.074 | 0.9831 | 0.9363 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7500.074 | 0.8525 | 0.4782 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7500.074 | 0.9371 | 0.7685 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7500.074 | 0.9181 | 0.7011 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7500.074 | 0.8581 | 0.4966 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7500.074 | 0.5689 | -0.3130 | 0.5279 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7504.074 | 1.1082 | 1.1113 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7504.074 | 1.1629 | 1.1657 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7504.074 | 1.0929 | 1.0960 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7504.074 | 1.0924 | 1.0954 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7504.074 | 1.1905 | 1.1927 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7504.074 | 0.8517 | 0.8377 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7504.074 | 0.3922 | 0.2208 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7504.074 | 0.0983 | -0.4116 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7504.074 | 0.0528 | -0.5760 | 1.8962 | |
| MDA-MB-361 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7506.074 | 0.9495 | 0.9170 | 1.2231 |