Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7452.074 | 0.2170 | -0.2700 | 1.5162 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7452.074 | 0.1823 | -0.3493 | 1.5162 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.000853 | uM | 7453.074 | 1.0019 | 1.0024 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.00427 | uM | 7453.074 | 0.9745 | 0.9677 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.0213 | uM | 7453.074 | 1.0459 | 1.0574 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.107 | uM | 7453.074 | 0.9950 | 0.9937 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 0.533 | uM | 7453.074 | 0.9978 | 0.9973 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 2.67 | uM | 7453.074 | 0.7400 | 0.6544 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 13.3 | uM | 7453.074 | 0.4441 | 0.1992 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7453.074 | 0.2196 | -0.2304 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7453.074 | 0.1735 | -0.3367 | 1.5871 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.000853 | uM | 7456.074 | 0.8807 | 0.8748 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.00427 | uM | 7456.074 | 1.0755 | 1.0755 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.0213 | uM | 7456.074 | 1.0340 | 1.0343 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.107 | uM | 7456.074 | 0.9925 | 0.9923 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.533 | uM | 7456.074 | 0.6928 | 0.6592 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 2.67 | uM | 7456.074 | 0.4384 | 0.3145 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 13.3 | uM | 7456.074 | 0.2172 | -0.0805 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7456.074 | 0.0371 | -0.6262 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7456.074 | 0.0286 | -0.6725 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.000853 | uM | 7457.074 | 0.9037 | 0.8810 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.00427 | uM | 7457.074 | 0.8477 | 0.8096 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.0213 | uM | 7457.074 | 0.9170 | 0.8978 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.107 | uM | 7457.074 | 0.8739 | 0.8432 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 0.533 | uM | 7457.074 | 0.6781 | 0.5807 | 1.6514 |