Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 0.0032 | uM | 9511.002 | 0.4264 | -0.0194 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 0.016 | uM | 9511.002 | 0.2259 | -0.4234 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 0.08 | uM | 9511.002 | 0.1664 | -0.5534 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 0.4 | uM | 9511.002 | 0.1773 | -0.5291 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 2 | uM | 9511.002 | 0.2091 | -0.4596 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10 | uM | 9511.002 | 0.3060 | -0.2569 | 1.1960 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 9536.002 | 1.0110 | 1.0161 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 9536.002 | 1.0261 | 1.0381 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 9536.002 | 0.9758 | 0.9643 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.0032 | uM | 9536.002 | 0.7389 | 0.6017 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.016 | uM | 9536.002 | 0.3780 | -0.0206 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.08 | uM | 9536.002 | 0.2684 | -0.2382 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.4 | uM | 9536.002 | 0.2606 | -0.2545 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 2 | uM | 9536.002 | 0.2715 | -0.2318 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10 | uM | 9536.002 | 0.2677 | -0.2397 | 1.3627 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 10264.002 | 1.0613 | 1.0987 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 10264.002 | 1.1280 | 1.2048 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 10264.002 | 1.0598 | 1.0962 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.0032 | uM | 10264.002 | 0.8647 | 0.7780 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.016 | uM | 10264.002 | 0.6214 | 0.3609 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.08 | uM | 10264.002 | 0.5357 | 0.2069 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.4 | uM | 10264.002 | 0.4578 | 0.0627 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 2 | uM | 10264.002 | 0.5095 | 0.1588 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10 | uM | 10264.002 | 0.5021 | 0.1452 | 1.2356 | |
| MCF 10A | NM | Basal B | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 7867.002 | 0.9847 | 0.9871 | 2.3763 |