Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Dichloroacetate | PDK | PDK | 0.667 | uM | 13562.176 | 0.9737 | 0.9362 | 0.8217 | |
| MDA-MB-453 | TNBC | Luminal | Dichloroacetate | PDK | PDK | 3.33 | uM | 13562.176 | 0.8713 | 0.6913 | 0.8217 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.00000853 | uM | 12667.176 | 1.0237 | 1.0602 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 12667.176 | 1.0046 | 1.0115 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.000213 | uM | 12667.176 | 1.0044 | 1.0111 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.00107 | uM | 12667.176 | 1.0196 | 1.0498 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.00533 | uM | 12667.176 | 1.0304 | 1.0774 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.0267 | uM | 12667.176 | 0.9878 | 0.9692 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.133 | uM | 12667.176 | 0.9928 | 0.9817 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 0.667 | uM | 12667.176 | 0.9975 | 0.9936 | 0.7898 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 3.33 | uM | 12667.176 | 0.9327 | 0.8312 | 0.7898 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.00000853 | uM | 12999.176 | 0.9502 | 0.9028 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 12999.176 | 0.9599 | 0.9218 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.000213 | uM | 12999.176 | 0.9964 | 0.9930 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.00107 | uM | 12999.176 | 0.9874 | 0.9755 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.00533 | uM | 12999.176 | 0.9881 | 0.9768 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.0267 | uM | 12999.176 | 0.9423 | 0.8874 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.133 | uM | 12999.176 | 0.9239 | 0.8513 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 0.667 | uM | 12999.176 | 0.9434 | 0.8894 | 1.0250 | |
| SK-BR-3 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 3.33 | uM | 12999.176 | 0.9328 | 0.8687 | 1.0250 | |
| SUM1315MO2 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 0.00000853 | uM | 13761.176 | 0.9567 | 0.7818 | 0.3832 | |
| SUM1315MO2 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 13761.176 | 0.9775 | 0.8847 | 0.3832 | |
| SUM1315MO2 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 0.000213 | uM | 13761.176 | 0.9983 | 0.9910 | 0.3832 | |
| SUM1315MO2 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 0.00107 | uM | 13761.176 | 1.0030 | 1.0157 | 0.3832 | |
| SUM1315MO2 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 0.00533 | uM | 13761.176 | 0.9778 | 0.8864 | 0.3832 |