Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12365.155 | 0.3738 | 0.2550 | 2.1113 | |
| MCF12A | NM | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12365.155 | 0.5009 | 0.4415 | 2.1113 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10997.155 | 1.0612 | 1.0924 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10997.155 | 1.0188 | 1.0285 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10997.155 | 0.9445 | 0.9151 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10997.155 | 0.9859 | 0.9785 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10997.155 | 0.9664 | 0.9487 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10997.155 | 0.8249 | 0.7278 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10997.155 | 0.3853 | -0.0312 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10997.155 | 0.9421 | 0.9113 | 1.3159 | |
| MCF7 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10997.155 | 0.6857 | 0.5015 | 1.3159 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10998.155 | 0.9607 | 0.9156 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10998.155 | 0.9836 | 0.9647 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10998.155 | 0.8880 | 0.7603 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10998.155 | 0.9470 | 0.8864 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10998.155 | 0.9354 | 0.8615 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10998.155 | 0.9673 | 0.9299 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10998.155 | 0.5287 | 0.0081 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10998.155 | 0.9725 | 0.9410 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10998.155 | 0.7164 | 0.3974 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12206.155 | 1.0027 | 1.0056 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12206.155 | 1.0248 | 1.0505 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12206.155 | 0.9941 | 0.9879 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12206.155 | 0.9877 | 0.9748 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12206.155 | 0.9892 | 0.9780 | 0.9802 |