Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12206.155 | 0.8846 | 0.7649 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12206.155 | 0.2674 | -0.4792 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12206.155 | 1.0076 | 1.0155 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12206.155 | 0.8302 | 0.6542 | 0.9802 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12594.155 | 1.0851 | 1.1212 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12594.155 | 1.0069 | 1.0099 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12594.155 | 0.9505 | 0.9281 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12594.155 | 0.9607 | 0.9431 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12594.155 | 1.0290 | 1.0417 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12594.155 | 0.7348 | 0.6016 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12594.155 | 0.5988 | 0.3818 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12594.155 | 0.6873 | 0.5262 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12594.155 | 0.6446 | 0.4574 | 1.3872 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10642.146 | 1.0126 | 1.0348 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10642.146 | 0.9669 | 0.9097 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10642.146 | 1.0349 | 1.0966 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10642.146 | 1.0036 | 1.0099 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10642.146 | 0.9629 | 0.8987 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10642.146 | 0.9720 | 0.9234 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10642.146 | 0.9165 | 0.7740 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10642.146 | 0.5172 | -0.1923 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10642.146 | 0.7846 | 0.4328 | 0.7272 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10818.155 | 0.9848 | 0.9501 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10818.155 | 0.9323 | 0.7812 | 0.6048 | |
| MDA-MB-175-VII | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10818.155 | 0.9457 | 0.8238 | 0.6048 |