Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9760.121 | 0.2709 | -0.4397 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10127.121 | 1.0332 | 1.0598 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10127.121 | 1.1356 | 1.2430 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10127.121 | 1.0084 | 1.0151 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10127.121 | 0.9550 | 0.9187 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 10127.121 | 1.0957 | 1.1718 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 10127.121 | 0.9045 | 0.8269 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 10127.121 | 0.7002 | 0.4503 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 10127.121 | 0.4163 | -0.0927 | 1.1088 | |
| SK-BR-3 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10127.121 | 0.1687 | -0.5982 | 1.1088 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9777.121 | 0.8505 | 0.7479 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9777.121 | 0.8044 | 0.6688 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9777.121 | 0.7617 | 0.5946 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9777.121 | 0.9377 | 0.8958 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 9777.121 | 0.8017 | 0.6641 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 9777.121 | 0.9057 | 0.8419 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 9777.121 | 0.8483 | 0.7442 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 9777.121 | 0.7221 | 0.5254 | 1.2018 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 9777.121 | 0.0444 | -0.8501 | 1.2018 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7529.078 | 0.9935 | 0.9829 | 0.7619 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7529.078 | 0.9873 | 0.9667 | 0.7619 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7529.078 | 0.9381 | 0.8391 | 0.7619 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7529.078 | 0.9604 | 0.8966 | 0.7619 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 7529.078 | 0.9918 | 0.9785 | 0.7619 | |
| SUM1315MO2 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 7529.078 | 0.9215 | 0.7964 | 0.7619 |