Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 9469.121 | 0.2181 | -0.4804 | 1.1298 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 9469.121 | 0.0724 | -0.8042 | 1.1298 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 9469.121 | 0.0600 | -0.8343 | 1.1298 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10268.007 | 1.2241 | 1.3283 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10268.007 | 1.1162 | 1.1723 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10268.007 | 1.0607 | 1.0906 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10268.007 | 1.0434 | 1.0649 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 10268.007 | 0.8854 | 0.8252 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 10268.007 | 0.4112 | 0.0256 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 10268.007 | 0.0945 | -0.6604 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 10268.007 | 0.0416 | -0.8168 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 10268.007 | 0.0163 | -0.9094 | 1.3306 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7860.043 | 1.0234 | 1.0628 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7860.043 | 1.0096 | 1.0256 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7860.043 | 0.9534 | 0.8765 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7860.043 | 0.9836 | 0.9563 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7860.043 | 0.9970 | 0.9921 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7860.043 | 0.9904 | 0.9745 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7860.043 | 1.0053 | 1.0142 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7860.043 | 0.9933 | 0.9822 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7860.043 | 0.9947 | 0.9859 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9501.121 | 1.1166 | 1.3350 | 0.7121 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9501.121 | 1.0795 | 1.2269 | 0.7121 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9501.121 | 1.0386 | 1.1093 | 0.7121 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9501.121 | 1.0213 | 1.0602 | 0.7121 |