Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 9254.049 | 1.0501 | 1.1152 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 9254.049 | 1.0812 | 1.1871 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 4 | uM | 9254.049 | 1.1658 | 1.3843 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 20 | uM | 9254.049 | 1.1039 | 1.2398 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 100 | uM | 9254.049 | 1.0844 | 1.1945 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 500 | uM | 9254.049 | 1.0980 | 1.2260 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9258.03 | 1.0306 | 1.1557 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9258.03 | 1.1336 | 1.7329 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9258.03 | 1.1486 | 1.8244 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9258.03 | 1.0758 | 1.3991 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9258.03 | 0.9722 | 0.8643 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9258.03 | 0.7648 | 0.0256 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9258.03 | 0.3531 | -0.8503 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9258.03 | 0.0773 | -0.9966 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9258.03 | 0.0024 | -1.0000 | 0.4015 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7820.017 | 0.9569 | 0.8764 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7820.017 | 0.9786 | 0.9384 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7820.017 | 0.9809 | 0.9449 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7820.017 | 0.9238 | 0.7834 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7820.017 | 0.9932 | 0.9805 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7820.017 | 1.0124 | 1.0358 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7820.017 | 0.7515 | 0.3231 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7820.017 | 0.3351 | -0.5884 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7820.017 | 0.0700 | -0.9572 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7821.017 | 1.1497 | 1.8895 | 0.3792 |