Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9118.017 | 0.9793 | 0.9601 | 1.0401 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9118.017 | 0.8611 | 0.7322 | 1.0401 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9118.017 | 0.2654 | -0.4413 | 1.0401 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9118.017 | 0.2061 | -0.5620 | 1.0401 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9120.021 | 1.0512 | 1.1599 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9120.021 | 0.9659 | 0.8959 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9120.021 | 1.0386 | 1.1202 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9120.021 | 1.0014 | 1.0044 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9120.021 | 1.0008 | 1.0025 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9120.021 | 0.9953 | 0.9854 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9120.021 | 1.0225 | 1.0698 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9120.021 | 0.7331 | 0.2393 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9120.021 | 0.1367 | -0.9070 | 0.6486 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7793.035 | 1.0277 | 1.0456 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7793.035 | 0.9789 | 0.9651 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7793.035 | 1.0174 | 1.0287 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7793.035 | 0.9407 | 0.9016 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7793.035 | 1.0181 | 1.0298 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7793.035 | 0.5282 | 0.1812 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7793.035 | 0.1165 | -0.6607 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7793.035 | 0.0058 | -0.9713 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7793.035 | 0.0046 | -0.9763 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7794.017 | 1.0853 | 1.0842 | 1.9851 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7794.017 | 1.0567 | 1.0564 | 1.9851 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7794.017 | 1.0383 | 1.0382 | 1.9851 |