Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9958.034 | 0.0589 | -0.9912 | 0.5217 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9972.125 | 1.0703 | 1.1180 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 9972.125 | 0.9638 | 0.9388 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9972.125 | 1.0236 | 1.0397 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9972.125 | 0.8979 | 0.8263 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9972.125 | 0.8038 | 0.6635 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9972.125 | 0.6322 | 0.3584 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9972.125 | 0.6515 | 0.3934 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9972.125 | 0.6420 | 0.3761 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9972.125 | 0.1870 | -0.5139 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9997.026 | 1.0605 | 1.1062 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 9997.026 | 0.9842 | 0.9721 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9997.026 | 1.0645 | 1.1132 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9997.026 | 0.9146 | 0.8487 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9997.026 | 0.8619 | 0.7545 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9997.026 | 0.8275 | 0.6926 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9997.026 | 0.8818 | 0.7902 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9997.026 | 0.7679 | 0.5846 | 1.1348 | ||
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9997.026 | 0.1305 | -0.6676 | 1.1348 | ||
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.000171 | uM | 10581.14 | 0.9994 | 0.9987 | 0.9569 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.000853 | uM | 10581.14 | 0.9372 | 0.8689 | 0.9569 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.00427 | uM | 10581.14 | 0.9372 | 0.8689 | 0.9569 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.0213 | uM | 10581.14 | 0.9422 | 0.8794 | 0.9569 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.107 | uM | 10581.14 | 0.9779 | 0.9539 | 0.9569 | |
| BT-20 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 0.533 | uM | 10581.14 | 0.9516 | 0.8990 | 0.9569 |