Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7900.018 | 0.6029 | 0.0874 | 0.8304 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7900.018 | 0.1776 | -0.7506 | 0.8304 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7902.018 | 1.2944 | 1.2961 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7902.018 | 0.9473 | 0.9428 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7902.018 | 1.2742 | 1.2769 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7902.018 | 0.8258 | 0.8053 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7902.018 | 0.9137 | 0.9057 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7902.018 | 0.7889 | 0.7616 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7902.018 | 0.5879 | 0.5051 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7902.018 | 0.7808 | 0.7519 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7902.018 | 0.3699 | 0.1746 | 1.8686 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10266.026 | 1.1713 | 1.5339 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 10266.026 | 0.9362 | 0.8121 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 10266.026 | 1.0854 | 1.2610 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 10266.026 | 0.8503 | 0.5691 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 10266.026 | 0.9193 | 0.7635 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 10266.026 | 0.8391 | 0.5383 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 10266.026 | 0.8387 | 0.5371 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 10266.026 | 0.6666 | 0.0901 | 0.6682 | ||
| MDA-MB-436 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 10266.026 | 0.1857 | -0.8390 | 0.6682 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9708.006 | 1.0444 | 1.1423 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 9708.006 | 0.9132 | 0.7320 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9708.006 | 1.0092 | 1.0291 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9708.006 | 0.6697 | 0.0598 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9708.006 | 0.4795 | -0.3757 | 0.6313 |