Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9708.006 | 0.7636 | 0.3046 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9708.006 | 0.6386 | -0.0171 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9708.006 | 0.8484 | 0.5415 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9708.006 | 0.3974 | -0.5364 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.00128 | uM | 9723.124 | 1.1537 | 1.3131 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.0064 | uM | 9723.124 | 0.9958 | 0.9915 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.032 | uM | 9723.124 | 0.9878 | 0.9752 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.16 | uM | 9723.124 | 0.7857 | 0.5646 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.8 | uM | 9723.124 | 0.8291 | 0.6527 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 4 | uM | 9723.124 | 0.7810 | 0.5553 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 20 | uM | 9723.124 | 0.7812 | 0.5556 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 100 | uM | 9723.124 | 0.7210 | 0.4338 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 500 | uM | 9723.124 | 0.7456 | 0.4835 | 0.9827 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7904.018 | 1.0809 | 1.1138 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7904.018 | 0.9800 | 0.9714 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7904.018 | 0.9186 | 0.8828 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7904.018 | 0.4465 | 0.1269 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7904.018 | 0.5119 | 0.2420 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7904.018 | 0.4514 | 0.1358 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7904.018 | 0.4769 | 0.1810 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 7904.018 | 0.4267 | 0.0911 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 7904.018 | 0.0463 | -0.7754 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7905.018 | 1.1269 | 1.2842 | 0.8988 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7905.018 | 0.7924 | 0.5437 | 0.8988 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7905.018 | 0.9057 | 0.7912 | 0.8988 |