Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7879.018 | 0.7411 | 0.6919 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7879.018 | 0.6719 | 0.6018 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7879.018 | 0.0086 | -0.8596 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10093.034 | 0.9614 | 0.9207 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 10093.034 | 1.0147 | 1.0303 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 10093.034 | 0.8867 | 0.7676 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 10093.034 | 0.7800 | 0.5494 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 10093.034 | 0.7866 | 0.5629 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 10093.034 | 0.7779 | 0.5451 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 10093.034 | 0.7282 | 0.4437 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 10093.034 | 0.6126 | 0.2087 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 10093.034 | 0.0083 | -0.9855 | 0.9732 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7884.018 | 1.1038 | 1.3530 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7884.018 | 1.0265 | 1.0879 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7884.018 | 1.0828 | 1.2799 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7884.018 | 0.8892 | 0.6484 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7884.018 | 0.8459 | 0.5184 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7884.018 | 0.8124 | 0.4207 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7884.018 | 0.9099 | 0.7121 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7884.018 | 0.8044 | 0.3978 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7884.018 | 0.3277 | -0.6812 | 0.6074 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7892.018 | 0.8831 | 0.9027 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7892.018 | 0.7434 | 0.7755 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7892.018 | 0.6810 | 0.7141 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7892.018 | 0.6672 | 0.7000 | 2.4903 |