Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7892.018 | 0.7413 | 0.7735 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7892.018 | 0.6682 | 0.7011 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7892.018 | 0.6651 | 0.6979 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7892.018 | 0.5500 | 0.5731 | 2.4903 | ||
| MDA-MB-231 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7892.018 | 0.0888 | -0.2437 | 2.4903 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7895.018 | 1.0390 | 1.0602 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7895.018 | 0.9571 | 0.9332 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7895.018 | 0.9250 | 0.8828 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7895.018 | 0.7783 | 0.6472 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7895.018 | 0.7851 | 0.6583 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7895.018 | 0.7522 | 0.6043 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7895.018 | 0.7350 | 0.5758 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7895.018 | 0.6725 | 0.4711 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7895.018 | 0.0312 | -0.8635 | 1.2916 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9648.026 | 1.0249 | 1.0709 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 9648.026 | 0.9895 | 0.9704 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9648.026 | 0.9933 | 0.9811 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9648.026 | 0.8682 | 0.6372 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9648.026 | 0.8685 | 0.6381 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9648.026 | 0.8645 | 0.6275 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9648.026 | 0.8668 | 0.6337 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9648.026 | 0.8080 | 0.4789 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9648.026 | 0.4906 | -0.2701 | 0.7065 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10095.034 | 1.0368 | 1.0939 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 10095.034 | 1.0851 | 1.2186 | 0.7874 |