Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 9386.037 | 0.0946 | -0.6487 | 1.3556 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7840.05 | 1.0023 | 1.0098 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7840.05 | 1.0597 | 1.2645 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7840.05 | 0.9578 | 0.8233 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7840.05 | 0.9049 | 0.6146 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7840.05 | 0.4639 | -0.6143 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7840.05 | 0.4901 | -0.5662 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7840.05 | 0.4706 | -0.6023 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7840.05 | 0.3556 | -0.7819 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7840.05 | 0.1852 | -0.9461 | 0.4666 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7844.037 | 0.9401 | 0.6740 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7844.037 | 0.9533 | 0.7423 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7844.037 | 1.0053 | 1.0307 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7844.037 | 0.8338 | 0.1848 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7844.037 | 0.5345 | -0.6709 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7844.037 | 0.4942 | -0.7375 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7844.037 | 0.4743 | -0.7669 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7844.037 | 0.3278 | -0.9196 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7844.037 | 0.4421 | -0.8095 | 0.3471 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9402.037 | 1.0019 | 1.0100 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9402.037 | 0.8655 | 0.3625 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9402.037 | 0.9448 | 0.7196 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9402.037 | 0.7335 | -0.1223 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9402.037 | 0.4892 | -0.7009 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9402.037 | 0.5006 | -0.6820 | 0.3763 |