Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 9386.026 | 0.4912 | 0.2674 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 9386.026 | 0.3420 | 0.0046 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 9386.026 | 0.2816 | -0.1132 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 9386.026 | 0.1709 | -0.3564 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 9386.026 | 0.0253 | -0.8112 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 9386.026 | 0.0100 | -0.8956 | 1.5583 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7840.018 | 1.0368 | 1.1836 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7840.018 | 0.9833 | 0.9197 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7840.018 | 0.9068 | 0.5766 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7840.018 | 0.7246 | -0.0862 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7840.018 | 0.8019 | 0.1692 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7840.018 | 0.7687 | 0.0552 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7840.018 | 0.7645 | 0.0413 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7840.018 | 0.4594 | -0.6981 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7840.018 | 0.0088 | -1.0000 | 0.4113 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7845.018 | 1.0137 | 1.0611 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7845.018 | 1.0392 | 1.1777 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7845.018 | 0.8939 | 0.5604 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7845.018 | 0.7194 | -0.0351 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7845.018 | 0.8008 | 0.2233 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7845.018 | 0.7890 | 0.1837 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7845.018 | 0.7484 | 0.0528 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7845.018 | 0.6699 | -0.1761 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7845.018 | 0.0717 | -0.9941 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9421.034 | 0.9276 | 0.7724 | 0.6220 |