Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 10262.034 | 0.7198 | 0.2184 | 0.6634 | ||
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 10262.034 | 0.6612 | 0.0720 | 0.6634 | ||
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 10262.034 | 0.3926 | -0.5114 | 0.6634 | ||
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 10262.034 | 0.1340 | -0.9033 | 0.6634 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7835.018 | 1.0640 | 1.2472 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7835.018 | 0.9314 | 0.7503 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7835.018 | 0.6664 | -0.0666 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7835.018 | 0.4844 | -0.4872 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7835.018 | 0.4225 | -0.6032 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7835.018 | 0.2826 | -0.8135 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7835.018 | 0.1190 | -0.9633 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 7835.018 | 0.0217 | -0.9985 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 7835.018 | 0.0010 | -1.0000 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7836.018 | 0.9147 | 0.8418 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7836.018 | 0.8986 | 0.8117 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7836.018 | 0.7682 | 0.5673 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7836.018 | 0.4401 | -0.0633 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7836.018 | 0.3550 | -0.2321 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7836.018 | 0.2771 | -0.3893 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7836.018 | 0.1266 | -0.7039 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 7836.018 | 0.0162 | -0.9557 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 7836.018 | 0.0100 | -0.9716 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9386.026 | 1.0622 | 1.0789 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 9386.026 | 0.9804 | 0.9747 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 9386.026 | 0.9111 | 0.8840 | 1.5583 |