Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9254.037 | 0.8396 | 0.6219 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9254.037 | 0.5864 | 0.0549 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 9254.037 | 0.5504 | -0.0222 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 9254.037 | 0.3902 | -0.3525 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 9254.037 | 0.3083 | -0.5117 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9258.037 | 1.0827 | 1.2407 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9258.037 | 1.0059 | 1.0169 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9258.037 | 1.0323 | 1.0932 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9258.037 | 0.9324 | 0.8096 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9258.037 | 0.7103 | 0.2263 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9258.037 | 0.5540 | -0.1406 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 9258.037 | 0.4954 | -0.2676 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 9258.037 | 0.3536 | -0.5479 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 9258.037 | 0.1752 | -0.8344 | 0.6992 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7818.05 | 0.9269 | 0.8428 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7818.05 | 0.9378 | 0.8662 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7818.05 | 0.8963 | 0.7772 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7818.05 | 0.8875 | 0.7584 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7818.05 | 0.4413 | -0.1721 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7818.05 | 0.3433 | -0.3686 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7818.05 | 0.3298 | -0.3953 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7818.05 | 0.2408 | -0.5692 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7818.05 | 0.0508 | -0.9195 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7820.04 | 1.0194 | 1.0529 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7820.04 | 0.9247 | 0.7987 | 0.7382 |