Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7931.016 | 0.9184 | 0.8746 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7931.016 | 0.8282 | 0.7330 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7931.016 | 0.8030 | 0.6927 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7932.016 | 1.0807 | 1.2559 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7932.016 | 1.0554 | 1.1744 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7932.016 | 1.0557 | 1.1754 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7932.016 | 0.9291 | 0.7843 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7932.016 | 1.0258 | 1.0805 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7932.016 | 0.9967 | 0.9898 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7932.016 | 0.9903 | 0.9698 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7932.016 | 0.8379 | 0.5202 | 0.6446 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7932.016 | 0.9202 | 0.7579 | 0.6446 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9972.019 | 1.0596 | 1.1117 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9972.019 | 0.9927 | 0.9863 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9972.019 | 1.0080 | 1.0151 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9972.019 | 0.9720 | 0.9474 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9972.019 | 0.9773 | 0.9574 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9972.019 | 0.8992 | 0.8102 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9972.019 | 0.8408 | 0.6996 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9972.019 | 0.6537 | 0.3419 | 1.0654 | ||
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9972.019 | 0.3967 | -0.1602 | 1.0654 | ||
| 184A1 | NM | Basal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9047.037 | 0.9096 | 0.6705 | 0.5262 | |
| 184A1 | NM | Basal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9047.037 | 1.0758 | 1.2981 | 0.5262 | |
| 184A1 | NM | Basal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9047.037 | 0.9396 | 0.7765 | 0.5262 | |
| 184A1 | NM | Basal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9047.037 | 0.4452 | -0.5704 | 0.5262 |